Dengue fever in humanized NOD/SCID mice

Dennis A. Bente, Michael W. Melkus, J. Victor Garcia, Rebeca Rico-Hesse

    Research output: Contribution to journalArticle

    127 Scopus citations

    Abstract

    The increased transmission and geographic spread of dengue fever (DF) and its more severe presentation, dengue hemorrhagic fever (DHF), make it the most important mosquito-borne viral disease of humans (50 to 100 million infections/year) (World Health Organization, Fact sheet 117, 2002). There are no vaccines or treatment for DF or DHF because there are no animal or other models of human disease; even higher primates do not show symptoms after infection (W. F. Scherer, P. K. Russell, L. Rosen, J. Casals, and R. W. Dickerman, Am. J. Trop. Med. Hyg. 27:590-599, 1978). We demonstrate that nonobese diabetic/severely compromised immunodeficient (NOD/SCID) mice xenografted with human CD34+ cells develop clinical signs of DF as in humans (fever, rash, and thrombocytopenia), when infected in a manner mimicking mosquito transmission (dose and mode). These results suggest this is a valuable model with which to study pathogenesis and test antidengue products.

    Original languageEnglish (US)
    Pages (from-to)13797-13799
    Number of pages3
    JournalJournal of virology
    Volume79
    Issue number21
    DOIs
    StatePublished - Nov 2005

    ASJC Scopus subject areas

    • Microbiology
    • Immunology
    • Insect Science
    • Virology

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    Bente, D. A., Melkus, M. W., Garcia, J. V., & Rico-Hesse, R. (2005). Dengue fever in humanized NOD/SCID mice. Journal of virology, 79(21), 13797-13799. https://doi.org/10.1128/JVI.79.21.13797-13799.2005