Dendritic cells: In the forefront of immunopathogenesis and vaccine development - A review

Mansour Mohamadzadeh, Ronald Luftig

Research output: Contribution to journalReview articlepeer-review

17 Scopus citations

Abstract

Dendritic cellls (DCs) comprise an essential component of the immune system. These cells, as antigen presenting cells (APCs) to nav̈e T cells, are crucial in the initiation of antigen specific immune responses. In the past years, several DC subsets have been identified in different organs which exert different effects in order to elicit adaptive immune responses. Thus, identification of such DC subsets has led to a better understanding of their distribution and function in the body. In this review, several key properties of the immunobiology, immunopathogenesis and vaccine strategies using DCs will be discussed.

Original languageEnglish (US)
Article number1
JournalJournal of Immune Based Therapies and Vaccines
Volume2
DOIs
StatePublished - Jan 13 2004
Externally publishedYes

Keywords

  • CD4/CD8 T cells
  • Dendritic cells
  • Immunopathogenesis
  • Th1/Th2 cells
  • Vaccine development
  • Vaccines

ASJC Scopus subject areas

  • Pharmacology
  • Immunology

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