Dendritic cell subsets differentially regulate angiogenesis in human ovarian cancer

Tyler J. Curiel, Pui Cheng, Peter Mottram, Xavier Alvarez, Lieve Moons, Melina Evdemon-Hogan, Shuang Wei, Linhua Zou, Ilona Kryczek, Gary Hoyle, Andrew Lackner, Peter Carmeliet, Weiping Zou

Research output: Contribution to journalArticle

203 Scopus citations

Abstract

Angiogenesis is essential for both primary and metastatic tumor growth. Tumor blood vessel formation is complex and regulated by many factors. Ovarian carcinomas have a poor prognosis, often associated with multifocal intraperitoneal dissemination accompanied by intense neovascularization. To examine tumor angiogenesis in the tumor microenvironment, we studied malignant ascites of patients with untreated ovarian carcinoma. We observed high numbers of plasmacytoid dendritic cells (PDCs) and significant stromal-derived factor (CXCL-12/SDF)-1 in their malignant ascites, attracting PDCs into the tumor environment. We now show that tumor-associated PDCs induced angiogenesis in vivo through production of tumor necrosis factor a and interleukin 8. By contrast, myeloid dendritic cells (MDCs) were absent from malignant ascites. MDCs derived in vitro suppressed angiogenesis in vivo through production of interleukin 12. Thus, the tumor may attract PDCs to augment angiogenesis while excluding MDCs to prevent angiogenesis inhibition, demonstrating a novel mechanism for modulating tumor neovascularization. Because dendritic cells (DCs) have long been known to affect tumor immunity, our data also implicate DCs in regulation of tumor neoangiogenesis, suggesting a novel role of DCs in tumor pathology.

Original languageEnglish (US)
Pages (from-to)5535-5538
Number of pages4
JournalCancer Research
Volume64
Issue number16
DOIs
StatePublished - Aug 15 2004

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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  • Cite this

    Curiel, T. J., Cheng, P., Mottram, P., Alvarez, X., Moons, L., Evdemon-Hogan, M., Wei, S., Zou, L., Kryczek, I., Hoyle, G., Lackner, A., Carmeliet, P., & Zou, W. (2004). Dendritic cell subsets differentially regulate angiogenesis in human ovarian cancer. Cancer Research, 64(16), 5535-5538. https://doi.org/10.1158/0008-5472.CAN-04-1272