Demystifying Cell Cycle Arrest by HIV-1 Vif

Daniel J. Salamango; Reuben S. Harris

doi:10.1016/j.tim.2021.01.001

Demystifying Cell Cycle Arrest by HIV-1 Vif

Daniel J. Salamango
, Reuben S. Harris

Research output: Contribution to journal › Short survey › peer-review

10 Scopus citations

Abstract

Although APOBEC3 degradation is the canonical function of HIV-1 Vif, this viral protein also induces potent cell cycle arrest through a newly defined mechanism. Here, we review recent advances in this area and propose that the scope of this activity may go beyond subversion of the host cell cycle.

Original language	English (US)
Pages (from-to)	381-384
Number of pages	4
Journal	Trends in Microbiology
Volume	29
Issue number	5
DOIs	https://doi.org/10.1016/j.tim.2021.01.001
State	Published - May 2021
Externally published	Yes

Keywords

G2/M cell cycle arrest
HIV-1
PPP2R5
Vif
host–pathogen interaction

ASJC Scopus subject areas

Microbiology (medical)
Infectious Diseases
Virology
Microbiology

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10.1016/j.tim.2021.01.001

Cite this

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title = "Demystifying Cell Cycle Arrest by HIV-1 Vif",

abstract = "Although APOBEC3 degradation is the canonical function of HIV-1 Vif, this viral protein also induces potent cell cycle arrest through a newly defined mechanism. Here, we review recent advances in this area and propose that the scope of this activity may go beyond subversion of the host cell cycle.",

keywords = "G2/M cell cycle arrest, HIV-1, PPP2R5, Vif, host–pathogen interaction",

author = "Salamango, \{Daniel J.\} and Harris, \{Reuben S.\}",

note = "Publisher Copyright: {\textcopyright} 2021 Elsevier Ltd",

year = "2021",

month = may,

doi = "10.1016/j.tim.2021.01.001",

language = "English (US)",

volume = "29",

pages = "381--384",

journal = "Trends in Microbiology",

issn = "0966-842X",

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TY - JOUR

T1 - Demystifying Cell Cycle Arrest by HIV-1 Vif

AU - Salamango, Daniel J.

AU - Harris, Reuben S.

PY - 2021/5

Y1 - 2021/5

N2 - Although APOBEC3 degradation is the canonical function of HIV-1 Vif, this viral protein also induces potent cell cycle arrest through a newly defined mechanism. Here, we review recent advances in this area and propose that the scope of this activity may go beyond subversion of the host cell cycle.

AB - Although APOBEC3 degradation is the canonical function of HIV-1 Vif, this viral protein also induces potent cell cycle arrest through a newly defined mechanism. Here, we review recent advances in this area and propose that the scope of this activity may go beyond subversion of the host cell cycle.

KW - G2/M cell cycle arrest

KW - HIV-1

KW - PPP2R5

KW - Vif

KW - host–pathogen interaction

UR - https://www.scopus.com/pages/publications/85100157185

UR - https://www.scopus.com/pages/publications/85100157185#tab=citedBy

U2 - 10.1016/j.tim.2021.01.001

DO - 10.1016/j.tim.2021.01.001

M3 - Short survey

C2 - 33478820

AN - SCOPUS:85100157185

SN - 0966-842X

VL - 29

SP - 381

EP - 384

JO - Trends in Microbiology

JF - Trends in Microbiology

IS - 5

ER -

Demystifying Cell Cycle Arrest by HIV-1 Vif

Abstract

Keywords

ASJC Scopus subject areas

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