Demystifying Cell Cycle Arrest by HIV-1 Vif

Daniel J. Salamango, Reuben S. Harris

Research output: Contribution to journalShort surveypeer-review

3 Scopus citations

Abstract

Although APOBEC3 degradation is the canonical function of HIV-1 Vif, this viral protein also induces potent cell cycle arrest through a newly defined mechanism. Here, we review recent advances in this area and propose that the scope of this activity may go beyond subversion of the host cell cycle.

Original languageEnglish (US)
Pages (from-to)381-384
Number of pages4
JournalTrends in Microbiology
Volume29
Issue number5
DOIs
StatePublished - May 2021
Externally publishedYes

Keywords

  • G2/M cell cycle arrest
  • HIV-1
  • host–pathogen interaction
  • PPP2R5
  • Vif

ASJC Scopus subject areas

  • Microbiology
  • Microbiology (medical)
  • Virology
  • Infectious Diseases

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