Demonstration of the medullary lamellac of the human red nucleus with high-resolution gradient-echo MR imaging

Y. Pu, Y. Liu, J. Hou, Peter T Fox, J. H. Gao

Research output: Contribution to journalArticle

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Abstract

BACKGROUND AND PURPOSE: The human red nucleus is not a uniform structure. It is composed of caudally located magnocellular and rostrally located parvicellular subnuclei. In fact, the latter forms the bulk of the human red nucleus and can be subdivided histologically by two medullary lamellae into three parts. Because iron is deposited in the human red nucleus and gradient-echo sequences are more sensitive than spin-echo sequences in the detection of iron, a high-resolution gradient-echo MR sequence was used in this study to determine whether the medullary lamellae of the normal human red nucleus could be detected in vivo. METHODS: Ten healthy volunteers (seven men and three women, 27-48 years old) were examined with a high-resolution T2*-weighted gradient-echo MR sequence using a 1.9-T MR imager. The scanning parameters were 60/40/15 (TR/TE/excitations) with a flip angle of 20°, a pixel size of 1 x 1 mm, and a slice thickness of 5 mm. RESULTS: The medullary lamellae were depicted in all subjects in three imaging planes: coronal, oblique axial and oblique sagittal. The signal intensity of the lamellae was consistently higher than that of other parts of the red nucleus on all images. With the lamellae, the parvicellular subnucleus of the human red nucleus can be divided into its subdivisions. CONCLUSION: High-resolution gradient-echo MR imaging is capable of depicting the medullary lamellae of the normal human red nucleus in vivo.

Original languageEnglish (US)
Pages (from-to)1243-1247
Number of pages5
JournalAmerican Journal of Neuroradiology
Volume21
Issue number7
StatePublished - 2000

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Red Nucleus
Iron
Healthy Volunteers

ASJC Scopus subject areas

  • Clinical Neurology
  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology

Cite this

Demonstration of the medullary lamellac of the human red nucleus with high-resolution gradient-echo MR imaging. / Pu, Y.; Liu, Y.; Hou, J.; Fox, Peter T; Gao, J. H.

In: American Journal of Neuroradiology, Vol. 21, No. 7, 2000, p. 1243-1247.

Research output: Contribution to journalArticle

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AU - Gao, J. H.

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N2 - BACKGROUND AND PURPOSE: The human red nucleus is not a uniform structure. It is composed of caudally located magnocellular and rostrally located parvicellular subnuclei. In fact, the latter forms the bulk of the human red nucleus and can be subdivided histologically by two medullary lamellae into three parts. Because iron is deposited in the human red nucleus and gradient-echo sequences are more sensitive than spin-echo sequences in the detection of iron, a high-resolution gradient-echo MR sequence was used in this study to determine whether the medullary lamellae of the normal human red nucleus could be detected in vivo. METHODS: Ten healthy volunteers (seven men and three women, 27-48 years old) were examined with a high-resolution T2*-weighted gradient-echo MR sequence using a 1.9-T MR imager. The scanning parameters were 60/40/15 (TR/TE/excitations) with a flip angle of 20°, a pixel size of 1 x 1 mm, and a slice thickness of 5 mm. RESULTS: The medullary lamellae were depicted in all subjects in three imaging planes: coronal, oblique axial and oblique sagittal. The signal intensity of the lamellae was consistently higher than that of other parts of the red nucleus on all images. With the lamellae, the parvicellular subnucleus of the human red nucleus can be divided into its subdivisions. CONCLUSION: High-resolution gradient-echo MR imaging is capable of depicting the medullary lamellae of the normal human red nucleus in vivo.

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