Demographic predictors of hospitalization and mortality in US children with COVID-19

Alvaro Moreira, Kevin Chorath, Karthik Rajasekaran, Fiona Burmeister, Mubbasheer Ahmed, Axel Moreira

Research output: Contribution to journalArticlepeer-review


Understanding which children are at increased risk for poor outcome with COVID-19 is critical. In this study, we link pediatric population–based data from the US Center for Disease Control and Prevention to COVID-19 hospitalization and in-hospital death. In 27,045 US children with confirmed COVID-19, we demonstrate that African American [OR 2.28 (95% CI: 1.93, 2.70)] or mixed race [OR 2.95 (95% CI: 2.28, 3.82)] and an underlying medical condition [OR 3.55 (95% CI: 3.14, 4.01)] are strong predictors for hospitalization. Death occurred in 39 (0.19%) of 20,096 hospitalized children; children with a prior medical condition had an increased odd for death [OR 8.8 (95% CI: 3.7, 21.1)]. Conclusion: Hospitalization and in-hospital death are rare in children diagnosed with COVID-19. However, children at higher risk for these outcomes include those with an underlying medical condition, as well as those of African American descent.What is Known:• Demographic factors are independent prognosticators of poor outcome in children with COVID-19.What is New:• Children with an underlying medical condition and those from an African American or mixed race/ethnicity are at high risk for COVID-19 hospitalization.• History of a comorbidity supersedes age, gender, and race/ethnicity as a risk factor for in-hospital pediatric COVID-19 death.

Original languageEnglish (US)
Pages (from-to)1659-1663
Number of pages5
JournalEuropean Journal of Pediatrics
Issue number5
StatePublished - May 2021


  • COVID-19
  • Children
  • Pediatric
  • SARS-CoV-2

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health


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