Delayed pharmacological effects of antidepressants

Alan Frazer, S. Benmansour

Research output: Contribution to journalArticle

75 Citations (Scopus)

Abstract

Although antidepressants may not be primary mood stabilizers, they are efficacious in the prophylaxis of recurrent depressive illnesses, as well as in the treatment of acute episodes. Pharmacological effects that may contribute to the prophylactic effects of these drugs are not understood. Studies have been carried out in which antidepressants have been given to laboratory animals, such as rats, for periods of up to 3-4 weeks. Data obtained in such studies are thought to be important for their beneficial effects in depressive episodes, but also may be relevant to their prophylactic effects. Results are presented showing that when selective inhibitors of serotonin or norepinephrine uptake are given for such time periods, they still produce selective effects on serotonergic or noradrenergic parameters. For example, long-term administration of selective norepinephrine reuptake inhibitors causes a down-regulation of β1 adrenoceptors. Selective serotonin reuptake inhibitors do not produce this effect. Longterm administration of selective serotonin reuptake inhibitors causes down-regulation of the serotonin transporter, but not the norepinephrine transporter. In contrast, selective norepinephrine reuptake inhibitors down-regulate the norepinephrine transporter but not the serotonin transporter. Substantial loss of serotonin transporter binding sites takes 15 days to occur and is accompanied by a marked reduction of serotonin transporter function in vivo.

Original languageEnglish (US)
JournalMolecular Psychiatry
Volume7
Issue numberSUPPL. 1
DOIs
StatePublished - 2002

Fingerprint

Serotonin Plasma Membrane Transport Proteins
Antidepressive Agents
Pharmacology
Norepinephrine Plasma Membrane Transport Proteins
Down-Regulation
Serotonin Uptake Inhibitors
Norepinephrine
Laboratory Animals
Adrenergic Receptors
Binding Sites
Pharmaceutical Preparations

Keywords

  • Norepinephrine transporter
  • Selective norepinephrine reuptake inhibitors
  • Selective serotonin reuptake inhibitors
  • Serotonin transporter

ASJC Scopus subject areas

  • Molecular Biology
  • Psychiatry and Mental health

Cite this

Delayed pharmacological effects of antidepressants. / Frazer, Alan; Benmansour, S.

In: Molecular Psychiatry, Vol. 7, No. SUPPL. 1, 2002.

Research output: Contribution to journalArticle

Frazer, Alan ; Benmansour, S. / Delayed pharmacological effects of antidepressants. In: Molecular Psychiatry. 2002 ; Vol. 7, No. SUPPL. 1.
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