Dehydroepiandrosterone (DHEA) replacement in postmenopausal women: Present status and future promise

Peter R. Casson, Peter J Hornsby, Husam F. Ghusn, John E. Buster

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Objective: Age-related declines in dehydroepiandroserone (DHEA) and dehydroepiandrosterone sulfate (DHEA-S) have been postulated to aggravate some diseases of the elderly. As a result, DHEA supplementation is often touted as the "fountain of youth" and is being used widely in an unregulated fashion, without evidence of efficacy or safety. Design: Review of the English-language literature. This review addresses DHEA replacement, touching on issues of bioavailability and possible beneficial effects. Safety concerns are also addressed. Conclusions: At present, we believe that DHEA replacement is not suitable for widespread clinical use; however, the potential for future hormonal therapy of aging with this compound is such that further investigation is certainly warranted.

Original languageEnglish (US)
Pages (from-to)225-231
Number of pages7
JournalMenopause
Volume4
Issue number4
StatePublished - 1997
Externally publishedYes

Fingerprint

Women's Rights
Dehydroepiandrosterone
Safety
Dehydroepiandrosterone Sulfate
Biological Availability
Language
Therapeutics

Keywords

  • Adrenal androgens
  • Aging
  • DHEA
  • DHEA replacement
  • DHEA-S
  • Hormonal replacement

ASJC Scopus subject areas

  • Obstetrics and Gynecology

Cite this

Casson, P. R., Hornsby, P. J., Ghusn, H. F., & Buster, J. E. (1997). Dehydroepiandrosterone (DHEA) replacement in postmenopausal women: Present status and future promise. Menopause, 4(4), 225-231.

Dehydroepiandrosterone (DHEA) replacement in postmenopausal women : Present status and future promise. / Casson, Peter R.; Hornsby, Peter J; Ghusn, Husam F.; Buster, John E.

In: Menopause, Vol. 4, No. 4, 1997, p. 225-231.

Research output: Contribution to journalArticle

Casson, PR, Hornsby, PJ, Ghusn, HF & Buster, JE 1997, 'Dehydroepiandrosterone (DHEA) replacement in postmenopausal women: Present status and future promise', Menopause, vol. 4, no. 4, pp. 225-231.
Casson, Peter R. ; Hornsby, Peter J ; Ghusn, Husam F. ; Buster, John E. / Dehydroepiandrosterone (DHEA) replacement in postmenopausal women : Present status and future promise. In: Menopause. 1997 ; Vol. 4, No. 4. pp. 225-231.
@article{4d92442a7b1c4fd68c26a5b5f9830db4,
title = "Dehydroepiandrosterone (DHEA) replacement in postmenopausal women: Present status and future promise",
abstract = "Objective: Age-related declines in dehydroepiandroserone (DHEA) and dehydroepiandrosterone sulfate (DHEA-S) have been postulated to aggravate some diseases of the elderly. As a result, DHEA supplementation is often touted as the {"}fountain of youth{"} and is being used widely in an unregulated fashion, without evidence of efficacy or safety. Design: Review of the English-language literature. This review addresses DHEA replacement, touching on issues of bioavailability and possible beneficial effects. Safety concerns are also addressed. Conclusions: At present, we believe that DHEA replacement is not suitable for widespread clinical use; however, the potential for future hormonal therapy of aging with this compound is such that further investigation is certainly warranted.",
keywords = "Adrenal androgens, Aging, DHEA, DHEA replacement, DHEA-S, Hormonal replacement",
author = "Casson, {Peter R.} and Hornsby, {Peter J} and Ghusn, {Husam F.} and Buster, {John E.}",
year = "1997",
language = "English (US)",
volume = "4",
pages = "225--231",
journal = "Menopause",
issn = "1072-3714",
publisher = "Lippincott Williams and Wilkins",
number = "4",

}

TY - JOUR

T1 - Dehydroepiandrosterone (DHEA) replacement in postmenopausal women

T2 - Present status and future promise

AU - Casson, Peter R.

AU - Hornsby, Peter J

AU - Ghusn, Husam F.

AU - Buster, John E.

PY - 1997

Y1 - 1997

N2 - Objective: Age-related declines in dehydroepiandroserone (DHEA) and dehydroepiandrosterone sulfate (DHEA-S) have been postulated to aggravate some diseases of the elderly. As a result, DHEA supplementation is often touted as the "fountain of youth" and is being used widely in an unregulated fashion, without evidence of efficacy or safety. Design: Review of the English-language literature. This review addresses DHEA replacement, touching on issues of bioavailability and possible beneficial effects. Safety concerns are also addressed. Conclusions: At present, we believe that DHEA replacement is not suitable for widespread clinical use; however, the potential for future hormonal therapy of aging with this compound is such that further investigation is certainly warranted.

AB - Objective: Age-related declines in dehydroepiandroserone (DHEA) and dehydroepiandrosterone sulfate (DHEA-S) have been postulated to aggravate some diseases of the elderly. As a result, DHEA supplementation is often touted as the "fountain of youth" and is being used widely in an unregulated fashion, without evidence of efficacy or safety. Design: Review of the English-language literature. This review addresses DHEA replacement, touching on issues of bioavailability and possible beneficial effects. Safety concerns are also addressed. Conclusions: At present, we believe that DHEA replacement is not suitable for widespread clinical use; however, the potential for future hormonal therapy of aging with this compound is such that further investigation is certainly warranted.

KW - Adrenal androgens

KW - Aging

KW - DHEA

KW - DHEA replacement

KW - DHEA-S

KW - Hormonal replacement

UR - http://www.scopus.com/inward/record.url?scp=0005944374&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0005944374&partnerID=8YFLogxK

M3 - Article

AN - SCOPUS:0005944374

VL - 4

SP - 225

EP - 231

JO - Menopause

JF - Menopause

SN - 1072-3714

IS - 4

ER -