TY - JOUR
T1 - Degradation of the proapoptotic proteins Bik, Puma, and Bim with Bcl-2 domain 3 homology in Chlamydia trachomatis-infected cells
AU - Dong, Feng
AU - Pirbhai, Mustak
AU - Xiao, Yangming
AU - Zhong, Youmin
AU - Wu, Yimou
AU - Zhong, Guangming
PY - 2005/3
Y1 - 2005/3
N2 - We have previously correlated Chlamydia trachomatis antiapoptotic activity with the blockade of mitochondrial cytochrome c release and the inhibition of Bax and Bak activation. We now report that C. trachomatis infection leads to degradation of Bik, Puma, and Bim, three upstream proapoptotic BH3-only proteins of the Bcl-2 family that can transmit death signals to mitochondria by inhibiting the Bcl-2 antiapoptotic proteins and/or activating the Bcl-2 proapoptotic members, such as Bax and Bak. This observation has provided new information on the chlamydial antiapoptosis mechanisms.
AB - We have previously correlated Chlamydia trachomatis antiapoptotic activity with the blockade of mitochondrial cytochrome c release and the inhibition of Bax and Bak activation. We now report that C. trachomatis infection leads to degradation of Bik, Puma, and Bim, three upstream proapoptotic BH3-only proteins of the Bcl-2 family that can transmit death signals to mitochondria by inhibiting the Bcl-2 antiapoptotic proteins and/or activating the Bcl-2 proapoptotic members, such as Bax and Bak. This observation has provided new information on the chlamydial antiapoptosis mechanisms.
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U2 - 10.1128/IAI.73.3.1861-1864.2005
DO - 10.1128/IAI.73.3.1861-1864.2005
M3 - Article
C2 - 15731089
AN - SCOPUS:15544375499
SN - 0019-9567
VL - 73
SP - 1861
EP - 1864
JO - Infection and immunity
JF - Infection and immunity
IS - 3
ER -