Degradation of the proapoptotic proteins Bik, Puma, and Bim with Bcl-2 domain 3 homology in Chlamydia trachomatis-infected cells

Feng Dong, Mustak Pirbhai, Yangming Xiao, Youmin Zhong, Yimou Wu, Guangming Zhong

Research output: Contribution to journalArticle

81 Scopus citations

Abstract

We have previously correlated Chlamydia trachomatis antiapoptotic activity with the blockade of mitochondrial cytochrome c release and the inhibition of Bax and Bak activation. We now report that C. trachomatis infection leads to degradation of Bik, Puma, and Bim, three upstream proapoptotic BH3-only proteins of the Bcl-2 family that can transmit death signals to mitochondria by inhibiting the Bcl-2 antiapoptotic proteins and/or activating the Bcl-2 proapoptotic members, such as Bax and Bak. This observation has provided new information on the chlamydial antiapoptosis mechanisms.

Original languageEnglish (US)
Pages (from-to)1861-1864
Number of pages4
JournalInfection and Immunity
Volume73
Issue number3
DOIs
StatePublished - Mar 1 2005

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ASJC Scopus subject areas

  • Parasitology
  • Microbiology
  • Immunology
  • Infectious Diseases

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