Degradation of centromeric histone H3 variant Cse4 requires the Fpr3 peptidyl-prolyl cis-trans isomerase

Kentaro Ohkuni, Rashid Abdulle, Katsumi Kitagawa

Research output: Contribution to journalArticle

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Abstract

The centromeric histone H3 variant Cse4 in Saccharomyces cerevisiae is polyubiquitylated and degraded in a proteasomedependent manner. We report here that the proline isomerase Fpr3 regulates Cse4 proteolysis. Structural change in Cse4 by Fpr3 might be important for the interaction between Cse4 and the E3 ubiquitin ligase Psh1.

Original languageEnglish (US)
Pages (from-to)1041-1045
Number of pages5
JournalGenetics
Volume196
Issue number4
DOIs
Publication statusPublished - Apr 2014

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ASJC Scopus subject areas

  • Genetics

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