Degradation of a cohesin subunit by the N-end rule pathway is essential for chromosome stability

E. Peter M. Candido, H. Rao, F. Uhlmann, K. Nasmyth, A. Varshavsky

Research output: Contribution to journalReview articlepeer-review

Abstract

This article demonstrates that the N-end rule pathway of ubiquitin-dependent proteolysis is required for degradation of a subunit of cohesin, a protein which functions to keep sister chromatids together at metaphase.

Original languageEnglish (US)
Pages (from-to)715-719
Number of pages5
JournalChemtracts
Volume14
Issue number13
StatePublished - Dec 1 2001
Externally publishedYes

ASJC Scopus subject areas

  • Chemistry(all)
  • Biochemistry
  • Molecular Biology

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