Degradation kinetics of a high porosity biodegradable scaffold

J. S. McKinney; K. A. Athanasiou; C. M. Agrawal

Degradation kinetics of a high porosity biodegradable scaffold

J. S. McKinney, K. A. Athanasiou, C. M. Agrawal

Orthopaedics

Research output: Contribution to conference › Paper › peer-review

Abstract

Porous poly(lactic-glycolic) acid (PLG) implants were fabricated using a modified salt-leaching technique. The in vitro degradation characteristics of these implants were then examined over 8 week period. The increase in dimensions of the implants between weeks 3 and 4 was due to polymer swelling. With time, this increase was overtaken by a loss in dimensions due to mass loss, which increased significantly after week 4. The implants exhibited a high level of degradation by week 8. The fabrication technique yielded highly porous implants with significant permeability. These characteristics make such implants ideal candidates for use as scaffolds for repair or regeneration of tissues.

Original language	English (US)
Number of pages	1
State	Published - 1998
Event	Proceedings of the 1998 17th Southern Biomedical Engineering Conference - San Antonio, TX, USA Duration: Feb 6 1998 → Feb 8 1998

Other

Other	Proceedings of the 1998 17th Southern Biomedical Engineering Conference
City	San Antonio, TX, USA
Period	2/6/98 → 2/8/98

ASJC Scopus subject areas

Engineering(all)

Cite this

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title = "Degradation kinetics of a high porosity biodegradable scaffold",

abstract = "Porous poly(lactic-glycolic) acid (PLG) implants were fabricated using a modified salt-leaching technique. The in vitro degradation characteristics of these implants were then examined over 8 week period. The increase in dimensions of the implants between weeks 3 and 4 was due to polymer swelling. With time, this increase was overtaken by a loss in dimensions due to mass loss, which increased significantly after week 4. The implants exhibited a high level of degradation by week 8. The fabrication technique yielded highly porous implants with significant permeability. These characteristics make such implants ideal candidates for use as scaffolds for repair or regeneration of tissues.",

author = "McKinney, {J. S.} and Athanasiou, {K. A.} and Agrawal, {C. M.}",

year = "1998",

language = "English (US)",

note = "Proceedings of the 1998 17th Southern Biomedical Engineering Conference ; Conference date: 06-02-1998 Through 08-02-1998",

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T1 - Degradation kinetics of a high porosity biodegradable scaffold

AU - McKinney, J. S.

AU - Athanasiou, K. A.

AU - Agrawal, C. M.

PY - 1998

Y1 - 1998

N2 - Porous poly(lactic-glycolic) acid (PLG) implants were fabricated using a modified salt-leaching technique. The in vitro degradation characteristics of these implants were then examined over 8 week period. The increase in dimensions of the implants between weeks 3 and 4 was due to polymer swelling. With time, this increase was overtaken by a loss in dimensions due to mass loss, which increased significantly after week 4. The implants exhibited a high level of degradation by week 8. The fabrication technique yielded highly porous implants with significant permeability. These characteristics make such implants ideal candidates for use as scaffolds for repair or regeneration of tissues.

AB - Porous poly(lactic-glycolic) acid (PLG) implants were fabricated using a modified salt-leaching technique. The in vitro degradation characteristics of these implants were then examined over 8 week period. The increase in dimensions of the implants between weeks 3 and 4 was due to polymer swelling. With time, this increase was overtaken by a loss in dimensions due to mass loss, which increased significantly after week 4. The implants exhibited a high level of degradation by week 8. The fabrication technique yielded highly porous implants with significant permeability. These characteristics make such implants ideal candidates for use as scaffolds for repair or regeneration of tissues.

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M3 - Paper

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T2 - Proceedings of the 1998 17th Southern Biomedical Engineering Conference

Y2 - 6 February 1998 through 8 February 1998

ER -

Degradation kinetics of a high porosity biodegradable scaffold

Abstract

Other

ASJC Scopus subject areas

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