Degradation and release characteristics of biodegradable carriers of trypsin inhibitor

K. A. Athanasiou, A. Singhal, C. M. Agrawal, S. Kindsvater, B. D. Boyan

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

The use of a biodegradable carrier system that provides a steady, controlled release of drugs or bioactive factors can be an attractive delivery vehicle of substances which can enhance repair processes in the musculoskeletal system. The present in vitro study examines the degradative and release characteristics of a 50:50 polylactic acid/polyglycolic acid implant, used as a carrier of trypsin inhibitor over a 10 week period. Morphological and scanning electron microscopic examinations demonstrate that the implant degrades in a gradual, extended fashion; by 10 weeks the implant is completely dissolved.It is also shown that the protein is released from the implant in a sigmoidal pattern with increased release between three and seven weeks. In order to further describe the degradative process of the implant, temporal changes in its molecular weight and surface axial strain were also determined. It is shown that in the initial four weeks there is a linear decrease in molecular weight of the implants. Axial strain decreased and then increases over time suggesting an initial period of stiffening followed by a period of degradative softening.

Original languageEnglish (US)
Title of host publicationAdvances in Bioengineering
EditorsJohn M. Tarbell
PublisherPubl by ASME
Pages603-606
Number of pages4
ISBN (Print)0791810313
StatePublished - 1993
EventProceedings of the 1993 ASME Winter Annual Meeting - New Orleans, LA, USA
Duration: Nov 28 1993Dec 3 1993

Publication series

NameAmerican Society of Mechanical Engineers, Bioengineering Division (Publication) BED
Volume26

Other

OtherProceedings of the 1993 ASME Winter Annual Meeting
CityNew Orleans, LA, USA
Period11/28/9312/3/93

ASJC Scopus subject areas

  • Engineering(all)

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