Definition and characterization of an extended social-affective default network

Maren Amft, Danilo Bzdok, Angela R. Laird, Peter T. Fox, Leonhard Schilbach, Simon B. Eickhoff

Research output: Contribution to journalArticlepeer-review

103 Scopus citations

Abstract

Recent evidence suggests considerable overlap between the default mode network (DMN) and regions involved in social, affective and introspective processes. We considered these overlapping regions as the social-affective part of the DMN. In this study, we established a robust mapping of the underlying brain network formed by these regions and those strongly connected to them (the extended social-affective default network). We first seeded meta-analytic connectivity modeling and resting-state analyses in the meta-analytically defined DMN regions that showed statistical overlap with regions associated with social and affective processing. Consensus connectivity of each seed was subsequently delineated by a conjunction across both connectivity analyses. We then functionally characterized the ensuing regions and performed several cluster analyses. Among the identified regions, the amygdala/hippocampus formed a cluster associated with emotional processes and memory functions. The ventral striatum, anterior cingulum, subgenual cingulum and ventromedial prefrontal cortex formed a heterogeneous subgroup associated with motivation, reward and cognitive modulation of affect. Posterior cingulum/precuneus and dorsomedial prefrontal cortex were associated with mentalizing, self-reference and autobiographic information. The cluster formed by the temporo-parietal junction and anterior middle temporal sulcus/gyrus was associated with language and social cognition. Taken together, the current work highlights a robustly interconnected network that may be central to introspective, socio-affective, that is, self- and other-related mental processes.

Original languageEnglish (US)
Pages (from-to)1031-1049
Number of pages19
JournalBrain Structure and Function
Volume220
Issue number2
DOIs
StatePublished - 2015

Keywords

  • Default mode network
  • Emotion
  • Meta-analytic connectivity modeling
  • Resting-state functional connectivity
  • Social cognition

ASJC Scopus subject areas

  • Anatomy
  • Neuroscience(all)
  • Histology

Fingerprint Dive into the research topics of 'Definition and characterization of an extended social-affective default network'. Together they form a unique fingerprint.

Cite this