Deferoxamine improves spatial memory performance following experimental brain injury in rats

Dorothy Longparma, Kamalika Ghosh, Anthony N. Moore, C. Edward Dixon, Pramod K. Dash

Research output: Contribution to journalArticle

64 Citations (Scopus)

Abstract

Traumatic brain injury (TBI) causes impairments of both motor and spatial memory performances. Research is only beginning to reveal the biochemical mechanism(s) underlying these deficits. It has been postulated that reactive oxygen species such as the superoxide and hydroxyl radicals, as well as the peroxynitrite anion, are generated by injury and may play a critical role in the observed memory deficits. The highly reactive hydroxyl radical, which is thought to contribute to neuronal toxicity, can be generated by an iron-catalyzed reaction. The source of this iron (or iron-bound proteins) could be a compromise of the blood-brain barrier, which can occur following TBI. In this report, we investigate the ability of deferoxamine, a scavenger of free iron, the hydroxyl radical and the peroxynitrite anion, to facilitate behavioral recovery following a controlled cortical impact of rats. Intraperitoneal administration of this drug prior to the injury did not affect the rate of recovery from motor deficits in comparison to vehicle (saline)-injected animals. However, deferoxamine-treated animals showed significant improvement in spatial memory performance in a Morris water maze task. Volumetric analysis of cortical tissue loss showed no significant differences between vehicle- and drug-injected animals. Similarly, histological examination of the hippocampus did not reveal any gross differences between the two groups. These results indicate that deferoxamine improves spatial memory performance, possibly through protection from neuronal dysfunction.

Original languageEnglish (US)
Pages (from-to)109-117
Number of pages9
JournalBrain Research
Volume717
Issue number1-2
DOIs
StatePublished - Apr 22 1996
Externally publishedYes

Fingerprint

Deferoxamine
Brain Injuries
Iron
Hydroxyl Radical
Peroxynitrous Acid
Anions
Aptitude
Memory Disorders
Wounds and Injuries
Blood-Brain Barrier
Superoxides
Pharmaceutical Preparations
Reactive Oxygen Species
Hippocampus
Spatial Memory
Water
Research
Proteins
Traumatic Brain Injury

Keywords

  • brain injury
  • deferoxamine
  • free radical
  • spatial memory

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Deferoxamine improves spatial memory performance following experimental brain injury in rats. / Longparma, Dorothy; Ghosh, Kamalika; Moore, Anthony N.; Dixon, C. Edward; Dash, Pramod K.

In: Brain Research, Vol. 717, No. 1-2, 22.04.1996, p. 109-117.

Research output: Contribution to journalArticle

Longparma, D, Ghosh, K, Moore, AN, Dixon, CE & Dash, PK 1996, 'Deferoxamine improves spatial memory performance following experimental brain injury in rats', Brain Research, vol. 717, no. 1-2, pp. 109-117. https://doi.org/10.1016/0006-8993(95)01500-0
Longparma, Dorothy ; Ghosh, Kamalika ; Moore, Anthony N. ; Dixon, C. Edward ; Dash, Pramod K. / Deferoxamine improves spatial memory performance following experimental brain injury in rats. In: Brain Research. 1996 ; Vol. 717, No. 1-2. pp. 109-117.
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