Defects in the regulation of β-catenin in colorectal cancer

P. Polakis, M. Hart, B. Rubinfeld

Research output: Contribution to journalArticlepeer-review

70 Scopus citations


The molecular events that contribute to the progression of colon cancer are beginning to unravel. An initiating and probably obligatory event is the oncogenic activation of β-catenin. This can come about by the loss of its negative regulator the adenomatous polyposis coli (APC) protein, or by mutations in the β-catenin gene that result in a more stable protein product. The interaction between APC and β-catenin, and additional proteins that affect assembly and signaling along this pathway, are discussed.

Original languageEnglish (US)
Pages (from-to)23-32
Number of pages10
JournalAdvances in experimental medicine and biology
StatePublished - Dec 1 2000
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)


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