Defects in the regulation of β-catenin in colorectal cancer

P. Polakis, M. Hart, B. Rubinfeld

Research output: Contribution to journalArticlepeer-review

70 Scopus citations

Abstract

The molecular events that contribute to the progression of colon cancer are beginning to unravel. An initiating and probably obligatory event is the oncogenic activation of β-catenin. This can come about by the loss of its negative regulator the adenomatous polyposis coli (APC) protein, or by mutations in the β-catenin gene that result in a more stable protein product. The interaction between APC and β-catenin, and additional proteins that affect assembly and signaling along this pathway, are discussed.

Original languageEnglish (US)
Pages (from-to)23-32
Number of pages10
JournalAdvances in experimental medicine and biology
Volume470
StatePublished - Dec 1 2000
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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