Defective neutrophil chemotaxis in juvenile periodontitis

Robert A Clark, R. C. Page, G. Wilde

Research output: Contribution to journalArticle

151 Citations (Scopus)

Abstract

Neutrophil chemotaxis was evaluated in 9 patients with juvenile periodontitis, with normal subjects and patients with the adult form of periodontitis as controls. Defective chemotactic responses were observed in neutrophils from 7 of 9 juvenile patients, and a reduced level of complement-derived chemotactic activity was demonstrated in serum from 4 patients. These determinations were normal in all the patients with adult periodontitis. Serum from 5 of the juvenile patients contained a heat-stable, non-dialyzable factor that markedly inhibited the chemotaxis of normal neutrophils. Thus the characteristic tissue destruction seen in juvenile periodontitis may be, at least in part, a consequence of a failure of host defense mechanisms.

Original languageEnglish (US)
Pages (from-to)694-700
Number of pages7
JournalInfection and Immunity
Volume18
Issue number3
StatePublished - 1977
Externally publishedYes

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Aggressive Periodontitis
Chemotaxis
Neutrophils
Chronic Periodontitis
Defense Mechanisms
Serum
Hot Temperature

ASJC Scopus subject areas

  • Immunology

Cite this

Defective neutrophil chemotaxis in juvenile periodontitis. / Clark, Robert A; Page, R. C.; Wilde, G.

In: Infection and Immunity, Vol. 18, No. 3, 1977, p. 694-700.

Research output: Contribution to journalArticle

Clark, RA, Page, RC & Wilde, G 1977, 'Defective neutrophil chemotaxis in juvenile periodontitis', Infection and Immunity, vol. 18, no. 3, pp. 694-700.
Clark, Robert A ; Page, R. C. ; Wilde, G. / Defective neutrophil chemotaxis in juvenile periodontitis. In: Infection and Immunity. 1977 ; Vol. 18, No. 3. pp. 694-700.
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