Defective neutrophil chemotaxis in juvenile periodontitis

R. A. Clark, R. C. Page, G. Wilde

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154 Scopus citations


Neutrophil chemotaxis was evaluated in 9 patients with juvenile periodontitis, with normal subjects and patients with the adult form of periodontitis as controls. Defective chemotactic responses were observed in neutrophils from 7 of 9 juvenile patients, and a reduced level of complement-derived chemotactic activity was demonstrated in serum from 4 patients. These determinations were normal in all the patients with adult periodontitis. Serum from 5 of the juvenile patients contained a heat-stable, non-dialyzable factor that markedly inhibited the chemotaxis of normal neutrophils. Thus the characteristic tissue destruction seen in juvenile periodontitis may be, at least in part, a consequence of a failure of host defense mechanisms.

Original languageEnglish (US)
Pages (from-to)694-700
Number of pages7
JournalInfection and immunity
Issue number3
StatePublished - 1977
Externally publishedYes

ASJC Scopus subject areas

  • Infectious Diseases
  • Parasitology
  • Microbiology
  • Immunology


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