Defective developmental and function of Bcl10-deficient follicular, marginal zone and B1 B cells

Liquan Xue, Stephan W. Morris, Carlos Orihuela, Elaine Tuomanen, Xiaoli Cui, Renren Wen, Demin Wang

Research output: Contribution to journalArticlepeer-review

154 Scopus citations

Abstract

Bcl10 is an intracellular protein essential for nuclear factor (NF)-κB activation after lymphocyte antigen receptor stimulation. Using knockout mice, we show that absence of Bcl10 impeded conversion from transitional type 2 to mature follicular B cells and caused substantial decreases in marginal zone and B1 B cells. Bcl10-deficient B cells showed no excessive apoptosis. However, both Bcl10-deficient follicular and marginal zone B cells failed to proliferate normally, although Bcl10-deficient marginal zone B cells uniquely failed to activate NF-κB efficiently after stimulation with lipopolysaccharide. Bcl10-deficient marginal zone B cells did not capture antigens, and Bcl10-deficient (Bcl10-l-) mice failed to initiate humoral responses, leading to an inability to clear blood-borne bacteria. Thus, Bcl10 is essential for the development of all mature B cell subsets.

Original languageEnglish (US)
Pages (from-to)857-865
Number of pages9
JournalNature Immunology
Volume4
Issue number9
DOIs
StatePublished - Sep 1 2003

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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