DEFECT IN NEUTROPHIL GRANULOCYTE CHEMOTAXIS IN JOB'S SYNDROME OF RECURRENT "COLD" STAPHYLOCOCCAL ABSCESSES

Harry R. Hill; Paul G. Quie; Henry F. Pabst; Hans D. Ochs; Robert A. Clark; Seymour J. Klebanoff; Ralph J. Wedgwood

doi:10.1016/S0140-6736(74)91942-4

DEFECT IN NEUTROPHIL GRANULOCYTE CHEMOTAXIS IN JOB'S SYNDROME OF RECURRENT "COLD" STAPHYLOCOCCAL ABSCESSES

Harry R. Hill
, Paul G. Quie
, Henry F. Pabst
, Hans D. Ochs
, Robert A. Clark
, Seymour J. Klebanoff
, Ralph J. Wedgwood

Research output: Contribution to journal › Article › peer-review

208 Scopus citations

Abstract

Neutrophil granulocyte function was investigated in four females with recurrent, " cold " staphylococcal abscesses and chronic eczema (Job's syndrome). Each of the patients had a profound defect in neutrophil granulocyte chemotaxis and very high serum-IgE levels. Neutrophil random migration, phagocytosis, and bactericidal activity were normal. The serum or plasma of the patients did not inhibit the chemotactic responsiveness of control neutrophils. The recurrent staphylococcal abscesses in patients with Job's syndrome may be related to defective neutrophil chemotaxis. Such abnormalities, in turn, may result directly or indirectly from the interaction of antigen, IgE, and sensitised leucocytes.

Original language	English (US)
Pages (from-to)	617-619
Number of pages	3
Journal	The Lancet
Volume	304
Issue number	7881
DOIs	https://doi.org/10.1016/S0140-6736(74)91942-4
State	Published - Sep 14 1974
Externally published	Yes

ASJC Scopus subject areas

General Medicine

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10.1016/S0140-6736(74)91942-4

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@article{9711c51ed08c4e2ebe6446471f0734e9,

title = "DEFECT IN NEUTROPHIL GRANULOCYTE CHEMOTAXIS IN JOB'S SYNDROME OF RECURRENT {"}COLD{"} STAPHYLOCOCCAL ABSCESSES",

abstract = "Neutrophil granulocyte function was investigated in four females with recurrent, {"} cold {"} staphylococcal abscesses and chronic eczema (Job's syndrome). Each of the patients had a profound defect in neutrophil granulocyte chemotaxis and very high serum-IgE levels. Neutrophil random migration, phagocytosis, and bactericidal activity were normal. The serum or plasma of the patients did not inhibit the chemotactic responsiveness of control neutrophils. The recurrent staphylococcal abscesses in patients with Job's syndrome may be related to defective neutrophil chemotaxis. Such abnormalities, in turn, may result directly or indirectly from the interaction of antigen, IgE, and sensitised leucocytes.",

author = "Hill, \{Harry R.\} and Quie, \{Paul G.\} and Pabst, \{Henry F.\} and Ochs, \{Hans D.\} and Clark, \{Robert A.\} and Klebanoff, \{Seymour J.\} and Wedgwood, \{Ralph J.\}",

note = "Funding Information: Howard Hughes Medical Institute. This work was support:.{\textquoteright} in part by U.S. Public Health Service grants nos. AI 0ssei Funding Information: HL 0053; a grant from the Twin Cities Diabetes Association, lin.!1.eapoJis; a grant (no. RR-37) from the General Clinical Research Centers Program of the Division of Research Resources, National Institutes of Health; and the Boeing Employees Good Neighbor Fund, Seattle. We thank Dr Andrew Reardon for referring patient 3, and Dr Robert Gerlin for referring patient 4, Dr Richard Estensen for advice, Bancy Hogan and Hattie Gray for technical assistance, and Marian Wallfred for secretarial aid.",

year = "1974",

month = sep,

day = "14",

doi = "10.1016/S0140-6736(74)91942-4",

language = "English (US)",

volume = "304",

pages = "617--619",

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issn = "0140-6736",

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T1 - DEFECT IN NEUTROPHIL GRANULOCYTE CHEMOTAXIS IN JOB'S SYNDROME OF RECURRENT "COLD" STAPHYLOCOCCAL ABSCESSES

AU - Hill, Harry R.

AU - Quie, Paul G.

AU - Pabst, Henry F.

AU - Ochs, Hans D.

AU - Clark, Robert A.

AU - Klebanoff, Seymour J.

AU - Wedgwood, Ralph J.

N1 - Funding Information: Howard Hughes Medical Institute. This work was support:.’ in part by U.S. Public Health Service grants nos. AI 0ssei Funding Information: HL 0053; a grant from the Twin Cities Diabetes Association, lin.!1.eapoJis; a grant (no. RR-37) from the General Clinical Research Centers Program of the Division of Research Resources, National Institutes of Health; and the Boeing Employees Good Neighbor Fund, Seattle. We thank Dr Andrew Reardon for referring patient 3, and Dr Robert Gerlin for referring patient 4, Dr Richard Estensen for advice, Bancy Hogan and Hattie Gray for technical assistance, and Marian Wallfred for secretarial aid.

PY - 1974/9/14

Y1 - 1974/9/14

N2 - Neutrophil granulocyte function was investigated in four females with recurrent, " cold " staphylococcal abscesses and chronic eczema (Job's syndrome). Each of the patients had a profound defect in neutrophil granulocyte chemotaxis and very high serum-IgE levels. Neutrophil random migration, phagocytosis, and bactericidal activity were normal. The serum or plasma of the patients did not inhibit the chemotactic responsiveness of control neutrophils. The recurrent staphylococcal abscesses in patients with Job's syndrome may be related to defective neutrophil chemotaxis. Such abnormalities, in turn, may result directly or indirectly from the interaction of antigen, IgE, and sensitised leucocytes.

AB - Neutrophil granulocyte function was investigated in four females with recurrent, " cold " staphylococcal abscesses and chronic eczema (Job's syndrome). Each of the patients had a profound defect in neutrophil granulocyte chemotaxis and very high serum-IgE levels. Neutrophil random migration, phagocytosis, and bactericidal activity were normal. The serum or plasma of the patients did not inhibit the chemotactic responsiveness of control neutrophils. The recurrent staphylococcal abscesses in patients with Job's syndrome may be related to defective neutrophil chemotaxis. Such abnormalities, in turn, may result directly or indirectly from the interaction of antigen, IgE, and sensitised leucocytes.

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IS - 7881

ER -

DEFECT IN NEUTROPHIL GRANULOCYTE CHEMOTAXIS IN JOB'S SYNDROME OF RECURRENT "COLD" STAPHYLOCOCCAL ABSCESSES

Abstract

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