Neutrophil granulocyte function was investigated in four females with recurrent, " cold " staphylococcal abscesses and chronic eczema (Job's syndrome). Each of the patients had a profound defect in neutrophil granulocyte chemotaxis and very high serum-IgE levels. Neutrophil random migration, phagocytosis, and bactericidal activity were normal. The serum or plasma of the patients did not inhibit the chemotactic responsiveness of control neutrophils. The recurrent staphylococcal abscesses in patients with Job's syndrome may be related to defective neutrophil chemotaxis. Such abnormalities, in turn, may result directly or indirectly from the interaction of antigen, IgE, and sensitised leucocytes.
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