TY - JOUR
T1 - Decreased testosterone and dehydroepiandrosterone sulfate concentrations are associated with increased insulin and glucose concentrations in nondiabetic men
AU - Haffner, Steven M.
AU - Valdez, Rodolfo A.
AU - Mykkänen, Leena
AU - Stern, Michael P.
AU - Katz, Michael S.
N1 - Funding Information:
From the Divisions of Clinical Epidemiology and Geriatrics and Gerontology, Department of Medicine, Universit) of Texas Health Science Center at San Antonio, San Antonio; and the Geriatric Research Education and Clinical Center, Audie L. Murphy Memoriul Veterans Hospital, San Antonio, TX. Submitted February 27, 1993; accepted July 27. 1993. Supported by grants from the National Heart, Lung, and Blood Institute (ROI HL-24799 and R37-HL36820) and by Medical Research filnds from the Department of Vetemns Affairs. R.A. V. was supported by the ADA Mentor-based Postdoctoral Fellowship Program. Address reprint reyuests to Michael S. Katz, MD, Ditaision of Geriatrics and Gerontology, Department of Medicine, University of Texas Health Science Center. 7703 Floyd Curl Dr. San Antonio, TX 78284. Copyright 0 1994 by W.B. Saunders Companv 0026-049519414305-0013$03.00/O
PY - 1994/5
Y1 - 1994/5
N2 - Although many studies indicate that increased androgenicity is associated with insulin resistance and hyperinsulinemia in both premenopausal and postmenopausal women, relatively few data are available on this relationship in men. We examined the association of sex hormone-binding globulin (SHBG), total and free testosterone, dehydroepiandrosterone sulfate (DHEA-SO4), and estradiol to glucose and insulin concentrations before and during an oral glucose tolerance test in 178 men from the San Antonio Heart Study, a population-based study of diabetes and cardiovascular disease. Total and free testosterone and DHEA-SO4 were significantly inversely associated with insulin concentrations. Free testosterone and DHEA-SO4 were also significantly inversely correlated with glucose concentrations. SHBG was weakly positively associated with glucose concentrations. Estradiol was not related to glucose or insulin concentrations. After adjustment for age, obesity, and body fat distribution, insulin concentrations remained significantly inversely correlated with free testosterone (r = -.23), total testosterone (r = -.21), and DHEA-SO4 (r = -.21; all P < .01). In conclusion, we observed that increased testosterone and DHEA-SO4 are associated with lower insulin concentrations in men. This is in striking contrast to women, where increased androgenicity is associated with insulin resistance and hyperinsulinemia.
AB - Although many studies indicate that increased androgenicity is associated with insulin resistance and hyperinsulinemia in both premenopausal and postmenopausal women, relatively few data are available on this relationship in men. We examined the association of sex hormone-binding globulin (SHBG), total and free testosterone, dehydroepiandrosterone sulfate (DHEA-SO4), and estradiol to glucose and insulin concentrations before and during an oral glucose tolerance test in 178 men from the San Antonio Heart Study, a population-based study of diabetes and cardiovascular disease. Total and free testosterone and DHEA-SO4 were significantly inversely associated with insulin concentrations. Free testosterone and DHEA-SO4 were also significantly inversely correlated with glucose concentrations. SHBG was weakly positively associated with glucose concentrations. Estradiol was not related to glucose or insulin concentrations. After adjustment for age, obesity, and body fat distribution, insulin concentrations remained significantly inversely correlated with free testosterone (r = -.23), total testosterone (r = -.21), and DHEA-SO4 (r = -.21; all P < .01). In conclusion, we observed that increased testosterone and DHEA-SO4 are associated with lower insulin concentrations in men. This is in striking contrast to women, where increased androgenicity is associated with insulin resistance and hyperinsulinemia.
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U2 - 10.1016/0026-0495(94)90202-X
DO - 10.1016/0026-0495(94)90202-X
M3 - Article
C2 - 8177048
AN - SCOPUS:0028297129
VL - 43
SP - 599
EP - 603
JO - Metabolism: Clinical and Experimental
JF - Metabolism: Clinical and Experimental
SN - 0026-0495
IS - 5
ER -