Decreased sex hormone-binding globulin predicts noninsulin-dependent diabetes mellitus in women but not in men

Steven M. Haffner, Rodolfo A. Valdez, Philip A. Morales, Helen P. Hazuda, Michael P. Stern

Research output: Contribution to journalArticlepeer-review

170 Scopus citations

Abstract

Sex hormones may influence risk factors for noninsulin-dependent diabetes mellitus (NIDDM). Decreased sex hormone-binding globulin (SHBG; an indirect measure of androgenicity) is associated with hyperinsulinemia and insulin resistance. We measured SHBG concentrations in 58 subjects who later converted to diabetes and 107 subjects who remained normoglycemic throughout the 8 yr of follow-up of the San Antonio Heart Study, a population-based study of diabetes and cardiovascular disease. Among premenopausal women, SHBG concentrations (nanomoles per L) were significantly lower in converters than in nonconverters (41.6 ± 12.4 vs. 74.4 ± 10.0; P = 0.004), but corresponding differences were not observed in postmenopausal women or in men. Since, however, analysis of variance suggested no significant interaction between menopausal status and conversion to NIDDM, we pooled pre- and postmenopausal women. Subsequent analysis indicated that SHBG concentrations predicted the development of NIDDM in women independently of glucose and insulin concentrations. We conclude that increased androgenicity, as assessed by decreased SHBG concentrations, is an important independent risk factor for NIDDM in women.

Original languageEnglish (US)
Pages (from-to)56-60
Number of pages5
JournalJournal of Clinical Endocrinology and Metabolism
Volume77
Issue number1
DOIs
StatePublished - Jul 1993

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Biochemistry
  • Endocrinology
  • Clinical Biochemistry
  • Biochemistry, medical

Fingerprint Dive into the research topics of 'Decreased sex hormone-binding globulin predicts noninsulin-dependent diabetes mellitus in women but not in men'. Together they form a unique fingerprint.

Cite this