Decreased plasma neurotrophin-4/5 levels in bipolar disorder patients in mania

Izabela G. Barbosa, Isabela B. Morato, Rodrigo B. Huguet, Fabio L. Rocha, Rodrigo Machado-Vieira, Antônio L. Teixeira

Research output: Contribution to journalArticlepeer-review

14 Scopus citations


Objective: To evaluate two poorly explored neurotrophins (NT), NT-3 and NT-4/5, in bipolar disorder (BD).

Methods: Forty patients with type I BD (18 in remission and 22 in mania) and 25 healthy controls matched for age, gender, and educational attainment were enrolled in this study. All subjects were assessed by the Mini-International Neuropsychiatric Interview; the Young Mania Rating Scale and the Hamilton Depression Rating Scale were used to evaluate severity of symptoms in BD patients. Plasma levels of NT-3 and NT-4/5 were measured by enzyme-linked immunosorbent assay (ELISA).

Results: BD patients in mania presented decreased NT-4/5 plasma levels in comparison with controls (p, 0.05). There were no significant differences in NT-3 plasma levels between BD patients and controls.

Conclusion: These findings corroborate the view that neurotrophin dysfunction is associated with mood states in patients with BD.

Original languageEnglish (US)
Pages (from-to)340-343
Number of pages4
JournalRevista Brasileira de Psiquiatria
Issue number4
StatePublished - Oct 1 2014
Externally publishedYes


  • Biomarker
  • Bipolar disorder
  • Depression
  • Mania
  • Neurotrophin

ASJC Scopus subject areas

  • Psychiatry and Mental health


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