Decreased plasma neurotrophin-4/5 levels in bipolar disorder patients in mania

Izabela G. Barbosa; Isabela B. Morato; Rodrigo B. Huguet; Fabio L. Rocha; Rodrigo Machado-Vieira; Antônio L. Teixeira

doi:10.1590/1516-4446-2014-1380

Decreased plasma neurotrophin-4/5 levels in bipolar disorder patients in mania

Izabela G. Barbosa, Isabela B. Morato, Rodrigo B. Huguet, Fabio L. Rocha, Rodrigo Machado-Vieira, Antônio L. Teixeira

Research output: Contribution to journal › Article › peer-review

15 Scopus citations

Abstract

Objective: To evaluate two poorly explored neurotrophins (NT), NT-3 and NT-4/5, in bipolar disorder (BD).

Methods: Forty patients with type I BD (18 in remission and 22 in mania) and 25 healthy controls matched for age, gender, and educational attainment were enrolled in this study. All subjects were assessed by the Mini-International Neuropsychiatric Interview; the Young Mania Rating Scale and the Hamilton Depression Rating Scale were used to evaluate severity of symptoms in BD patients. Plasma levels of NT-3 and NT-4/5 were measured by enzyme-linked immunosorbent assay (ELISA).

Results: BD patients in mania presented decreased NT-4/5 plasma levels in comparison with controls (p, 0.05). There were no significant differences in NT-3 plasma levels between BD patients and controls.

Conclusion: These findings corroborate the view that neurotrophin dysfunction is associated with mood states in patients with BD.

Original language	English (US)
Pages (from-to)	340-343
Number of pages	4
Journal	Revista Brasileira de Psiquiatria
Volume	36
Issue number	4
DOIs	https://doi.org/10.1590/1516-4446-2014-1380
State	Published - Oct 1 2014
Externally published	Yes

Keywords

Biomarker
Bipolar disorder
Depression
Mania
Neurotrophin

ASJC Scopus subject areas

Psychiatry and Mental health

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abstract = "Objective: To evaluate two poorly explored neurotrophins (NT), NT-3 and NT-4/5, in bipolar disorder (BD).Methods: Forty patients with type I BD (18 in remission and 22 in mania) and 25 healthy controls matched for age, gender, and educational attainment were enrolled in this study. All subjects were assessed by the Mini-International Neuropsychiatric Interview; the Young Mania Rating Scale and the Hamilton Depression Rating Scale were used to evaluate severity of symptoms in BD patients. Plasma levels of NT-3 and NT-4/5 were measured by enzyme-linked immunosorbent assay (ELISA).Results: BD patients in mania presented decreased NT-4/5 plasma levels in comparison with controls (p, 0.05). There were no significant differences in NT-3 plasma levels between BD patients and controls.Conclusion: These findings corroborate the view that neurotrophin dysfunction is associated with mood states in patients with BD.",

keywords = "Biomarker, Bipolar disorder, Depression, Mania, Neurotrophin",

author = "Barbosa, {Izabela G.} and Morato, {Isabela B.} and Huguet, {Rodrigo B.} and Rocha, {Fabio L.} and Rodrigo Machado-Vieira and Teixeira, {Ant{\^o}nio L.}",

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doi = "10.1590/1516-4446-2014-1380",

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AU - Barbosa, Izabela G.

AU - Morato, Isabela B.

AU - Huguet, Rodrigo B.

AU - Rocha, Fabio L.

AU - Machado-Vieira, Rodrigo

AU - Teixeira, Antônio L.

PY - 2014/10/1

Y1 - 2014/10/1

N2 - Objective: To evaluate two poorly explored neurotrophins (NT), NT-3 and NT-4/5, in bipolar disorder (BD).Methods: Forty patients with type I BD (18 in remission and 22 in mania) and 25 healthy controls matched for age, gender, and educational attainment were enrolled in this study. All subjects were assessed by the Mini-International Neuropsychiatric Interview; the Young Mania Rating Scale and the Hamilton Depression Rating Scale were used to evaluate severity of symptoms in BD patients. Plasma levels of NT-3 and NT-4/5 were measured by enzyme-linked immunosorbent assay (ELISA).Results: BD patients in mania presented decreased NT-4/5 plasma levels in comparison with controls (p, 0.05). There were no significant differences in NT-3 plasma levels between BD patients and controls.Conclusion: These findings corroborate the view that neurotrophin dysfunction is associated with mood states in patients with BD.

AB - Objective: To evaluate two poorly explored neurotrophins (NT), NT-3 and NT-4/5, in bipolar disorder (BD).Methods: Forty patients with type I BD (18 in remission and 22 in mania) and 25 healthy controls matched for age, gender, and educational attainment were enrolled in this study. All subjects were assessed by the Mini-International Neuropsychiatric Interview; the Young Mania Rating Scale and the Hamilton Depression Rating Scale were used to evaluate severity of symptoms in BD patients. Plasma levels of NT-3 and NT-4/5 were measured by enzyme-linked immunosorbent assay (ELISA).Results: BD patients in mania presented decreased NT-4/5 plasma levels in comparison with controls (p, 0.05). There were no significant differences in NT-3 plasma levels between BD patients and controls.Conclusion: These findings corroborate the view that neurotrophin dysfunction is associated with mood states in patients with BD.

KW - Biomarker

KW - Bipolar disorder

KW - Depression

KW - Mania

KW - Neurotrophin

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Decreased plasma neurotrophin-4/5 levels in bipolar disorder patients in mania

Abstract

Keywords

ASJC Scopus subject areas

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