Decreased Plasma Levels of Angiotensin-Converting Enzyme Among Patients With Bipolar Disorder

Marsal Sanches, Gabriela D. Colpo, Valeria A. Cuellar, Taya Bockmann, Deevakar Rogith, Jair C. Soares, Antonio L. Teixeira

Research output: Contribution to journalArticlepeer-review

7 Scopus citations


Background: Dysfunctions in the renin-angiotensin system (RAS) seem to be involved in the pathophysiology of several mental illness, including schizophrenia and mood disorders. We carried out a cross-sectional study assessing the levels of RAS-related molecules among bipolar disorder (BD) patients compared to healthy controls. Methods: our sample consisted of 30 outpatients with BD type 1 (10 males, 20 females, age = 35.53 ± 10.59 years, 14 euthymic, 16 experiencing mood episodes) and 30 healthy controls (10 males, 20 females, age = 34.83 ± 11.49 years). Plasma levels of angiotensin-converting enzyme (ACE), angiotensin-converting enzyme 2 (ACE2), angiotensin-II (Ang II), and angiotensin (1–7) [Ang-(1–7)] were determined by ELISA. Results: BD patients experiencing ongoing mood episodes had significantly lower ACE levels compared to controls (median: 459.00 vs. 514.10, p < 0.05). There was no association between the levels of these biomarkers and clinical parameters. Conclusion: Our findings support the involvement of RAS dysfunction in the pathophysiology of BD. Considering the potential therapeutic implications linked to a better understanding of the role of RAS dysfunction in BD, studies allowing a better characterization of RAS-related molecules level and activity across different mood states are of high interest.

Original languageEnglish (US)
Article number617888
JournalFrontiers in Neuroscience
StatePublished - Feb 11 2021
Externally publishedYes


  • angiotensin converting enzyme
  • angiotensin II
  • bipolar disorder
  • depression
  • mood disorders
  • renin-angiotensin system

ASJC Scopus subject areas

  • General Neuroscience


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