Decreased nitric oxide production following extremity ischemia and reperfusion

John Blebea, Bradley Bacik, Gregory Strothman, Leslie Myatt

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

BACKGROUND: Nitric oxide (NO), the endogenous vasodilator, is an important regulator of vascular tone. We investigated NO production following lower extremity ischemia. METHODS: Rabbits underwent 6 hours of bilateral leg ischemia followed by unrestricted reperfusion. Physiologic parameters were continuously measured and blood was assayed for NO2 and NO3. RESULTS: Acute ischemia of the lower extremities produced an immediate increase in mean arterial blood pressure while later reperfusion induced a significant decrease (P < 0.0005). There was a fall in femoral blood flow during reperfusion. NO2/NO3 concentrations decreased significantly to 89% of baseline values after ischemia and 77% after 1 hour of reperfusion (P < 0.005). A significantly higher mortality was found in association with decreased NO2/NO3 concentrations. CONCLUSIONS: Nitric oxide appears to be a regulator of regional blood flow during reperfusion following extremity ischemia. Decreased NO production may contribute to impaired regional blood flow and mortality.

Original languageEnglish (US)
Pages (from-to)158-162
Number of pages5
JournalAmerican Journal of Surgery
Volume172
Issue number2
DOIs
StatePublished - Aug 1996
Externally publishedYes

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Reperfusion
Nitric Oxide
Ischemia
Extremities
Regional Blood Flow
Lower Extremity
Arterial Pressure
Mortality
Thigh
Vasodilator Agents
Blood Vessels
Leg
Rabbits

ASJC Scopus subject areas

  • Surgery

Cite this

Decreased nitric oxide production following extremity ischemia and reperfusion. / Blebea, John; Bacik, Bradley; Strothman, Gregory; Myatt, Leslie.

In: American Journal of Surgery, Vol. 172, No. 2, 08.1996, p. 158-162.

Research output: Contribution to journalArticle

Blebea, John ; Bacik, Bradley ; Strothman, Gregory ; Myatt, Leslie. / Decreased nitric oxide production following extremity ischemia and reperfusion. In: American Journal of Surgery. 1996 ; Vol. 172, No. 2. pp. 158-162.
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