Decrease in particle-induced osteolysis in obese (ob/ob) mice

M. Von Knoch, D. E. Jewison, J. D. Sibonga, R. T. Turner, B. F. Morrey, F. Loer, D. J. Berry, S. P. Scully

Research output: Contribution to journalArticlepeer-review

21 Scopus citations

Abstract

There may be variability in the susceptibility of different individuals to osteolysis from wear debris, and it is not clear whether some individuals may have a genetic predisposition for a more marked osteolytic response. The purpose of this study in mice was to determine whether genetically determined obesity can alter the response to particulate debris. Polyethylene particles were implanted onto the calvaria of seven wild-type mice and seven obese mice (ob/ob). Calvaria from unimplanted wild-type and obese mice served as controls. Calvaria were harvested after 7 days, stained with toluidine blue and for tartrate-specific alkaline phosphatase, and analyzed by histomorphometry. The osteoclast number per mm total bone perimeter was 8.000±3.464 in wild-type animals with particles and 2.857±1.676 in ob/ob animals with particles (p=0.0002; Fisher's PLSD). Bone resorption was 1.895±0.713mm/ mm2 in wild-type animals with particles and 1.265±0.494mm/ mm2 in ob/ob animals with particles (p=0.0438; Fisher's PLSD). Particles induced a diminished osteolytic response in genetically determined obese mice, suggesting that obesity may have a protective role against particle-induced bone resorption - similar to obesity and osteoporosis. These important new findings may help to stimulate clinical studies which may define criteria to better identify patients at risk to develop particle-induced osteolysis.

Original languageEnglish (US)
Pages (from-to)4675-4681
Number of pages7
JournalBiomaterials
Volume25
Issue number19
DOIs
StatePublished - Aug 1 2004
Externally publishedYes

Keywords

  • Osteoclast
  • Osteolysis
  • Particulates
  • Polyethylene
  • Wear debris

ASJC Scopus subject areas

  • Bioengineering
  • Ceramics and Composites
  • Biophysics
  • Biomaterials
  • Mechanics of Materials

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