Deconstructing Pancreas Development to Reconstruct Human Islets from Pluripotent Stem Cells

Kristen D. McKnight, Pei Wang, Seung K. Kim

Research output: Contribution to journalReview articlepeer-review

51 Scopus citations

Abstract

There is considerable excitement about harnessing the potential of human stem cells to replace pancreatic islets that are destroyed in type 1 diabetes mellitus. However, our current understanding of the mechanisms underlying pancreas and islet ontogeny has come largely from the powerful genetic, developmental, and embryological approaches available in nonhuman organisms. Successful islet reconstruction from human pluripotent cells will require greater attention to "deconstructing" human pancreas and islet developmental biology and consistent application of conditional genetics, lineage tracing, and cell purification to stem cell biology.

Original languageEnglish (US)
Pages (from-to)300-308
Number of pages9
JournalCell Stem Cell
Volume6
Issue number4
DOIs
StatePublished - Apr 2 2010
Externally publishedYes

ASJC Scopus subject areas

  • Genetics
  • Molecular Medicine
  • Cell Biology

Fingerprint

Dive into the research topics of 'Deconstructing Pancreas Development to Reconstruct Human Islets from Pluripotent Stem Cells'. Together they form a unique fingerprint.

Cite this