Decline in Ocular Toxoplasmosis over 40 Years at a Tertiary Referral Practice in the United States

Joshua H. Hou, Sarju S. Patel, Asim V. Farooq, Asad A. Qadir, Howard H. Tessler, Debra A. Goldstein

Research output: Contribution to journalReview articlepeer-review

5 Scopus citations


Purpose: To identify whether there has been a decline in ocular toxoplasmosis at a tertiary uveitis practice. Methods: Retrospective review of new patients at the University of Illinois Uveitis Service from 1973 to 2012. Results: There were 6820 patients with adequate records for inclusion; 323 (4.7%) were diagnosed with ocular toxoplasmosis. There was a 78.0% decline in prevalence of ocular toxoplasmosis from 2008 to 2012 compared with 1973 to 1977. Compared with the aggregate uveitis population, toxoplasmosis patients were more likely to be Hispanic (p<0.0001) and less likely to be African American (p<0.0001). Ocular toxoplasmosis in Hispanics commonly occurred in foreign-born patients (85.3%). Conclusions: The diagnosis of ocular toxoplasmosis at our clinic declined, with Hispanics accounting for an increasing proportion of cases. These trends are consistent with the decreasing toxoplasmosis seropositivity in the United States, but may also reflect decreased referrals due to improved management of ocular toxoplasmosis in primary clinics.

Original languageEnglish (US)
Pages (from-to)577-583
Number of pages7
JournalOcular Immunology and Inflammation
Issue number4
StatePublished - May 19 2018
Externally publishedYes


  • Epidemiology
  • ocular infection
  • public health
  • seroprevalence
  • toxoplasmosis

ASJC Scopus subject areas

  • Immunology and Allergy
  • Ophthalmology


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