Damaging effect of SO2 on DNA in lung cells of rats

Ziqiang Meng, Ruijin Li, Juli Bai, Xin Zhang, Zhenhua Yang

Research output: Contribution to journalArticle

2 Scopus citations

Abstract

The damaging effect of subchronic SO2 inhalation on DNA in lung cells of rats was studied using single cell microgel electrophoresis technique (Comet assay). The result showed that the comet tail lengths increased significantly in lung cells of rats when the animals were treated with SO 2 of 28 mg/m3 (P < 0.01). The results also indicated that DNA in lung cells of male rats was more seriously damaged than that of female rats. In addition, compared with the control, the body weight of the rats decreased, and the weight ratio of lung to body increased. It is concluded that SO2 pollution has a potential damaging effect on genetic material DNA in lung cells of mammalian animals.

Original languageEnglish (US)
Pages (from-to)726-728
Number of pages3
JournalChinese Journal of Applied and Environmental Biology
Volume11
Issue number6
StatePublished - Dec 25 2005
Externally publishedYes

Keywords

  • Comet assay
  • DNA damage
  • Lung
  • Rats
  • Sulfur dioxide

ASJC Scopus subject areas

  • Applied Microbiology and Biotechnology
  • Genetics
  • Agronomy and Crop Science
  • Pollution

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