Abstract
The damaging effect of subchronic SO2 inhalation on DNA in lung cells of rats was studied using single cell microgel electrophoresis technique (Comet assay). The result showed that the comet tail lengths increased significantly in lung cells of rats when the animals were treated with SO 2 of 28 mg/m3 (P < 0.01). The results also indicated that DNA in lung cells of male rats was more seriously damaged than that of female rats. In addition, compared with the control, the body weight of the rats decreased, and the weight ratio of lung to body increased. It is concluded that SO2 pollution has a potential damaging effect on genetic material DNA in lung cells of mammalian animals.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 726-728 |
| Number of pages | 3 |
| Journal | Chinese Journal of Applied and Environmental Biology |
| Volume | 11 |
| Issue number | 6 |
| State | Published - Dec 25 2005 |
| Externally published | Yes |
Keywords
- Comet assay
- DNA damage
- Lung
- Rats
- Sulfur dioxide
ASJC Scopus subject areas
- Applied Microbiology and Biotechnology
- Genetics
- Agronomy and Crop Science
- Pollution