Daily time course of the contents in monoamines and their metabolites in the pineal gland of Syrian hamster

Fátima Moujir, Celsa Santana, Francisco J. Hernández, Russel J. Reiter, Pedro Abreu

Research output: Contribution to journalArticle

8 Scopus citations

Abstract

Twenty-four h changes in endogenous tyrosine hydroxylase (TH) activity, monoamines and their metabolites as well as N-acetyltransferase (NAT) activity and melatonin content were investigated in the Syrian hamster pineal gland. Both NAT activity and melatonin content exhibited an expected rise 8 h (0400 h) after darkness onset. Pineal dopamine (DA) and 3,4-dihydroxyphenyl acetic acid (DOPAC) levels were highest during the dark phase reaching a peak at 0200 h, just prior to the rise in melatonin production. However no significant difference were found in both norepinephrine (NE) and TH activity levels during the 24 h period. However, in the present study, the rat pineal gland exhibited a clear day/night difference in its TH activity. These data suggest a possible role of pineal DA in the induction of melatonin synthesis in addition to its function as a NE precursor in the Syrian hamster pineal gland and also indicate that catecholamines may act on the hamster pineal in a different manner than in the rat.

Original languageEnglish (US)
Pages (from-to)77-80
Number of pages4
JournalNeuroscience Letters
Volume223
Issue number2
DOIs
StatePublished - Feb 21 1997

Keywords

  • N-acetyltransferase activity
  • dopamine
  • melatonin
  • tyrosine hydroxylase activity

ASJC Scopus subject areas

  • Neuroscience(all)

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