Daily mirfentanil induces (cross-) tolerance to the rate-decreasing effects of morphine and not mirfentanil

C. A. Gauthier, J. R. Bagley, L. L. Brockunier, Charles P France

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

The fentanyl derivative mirfentanil has a novel set of behavioral effects in non-humans including low-efficacy opioid actions and non-opioid antinociceptive actions. This study evaluated the rate decreasing effects of mirfentanil, morphine, naltrexone and ketamine in pigeons both prior to and during a period of chronic treatment with mirfentanil (3.2-17.8 mg/kg/day). Daily treatment with mirfentanil did not modify the rate-decreasing effects of mirfentanil or ketamine; however, daily treatment decreased sensitivity to the rate decreasing effects of morphine and increased sensitivity to naltrexone. These results demonstrate a lack of tolerance to an apparently non-opioid action (rate-decreasing effect) of mirfentanil, which might predict a lack of tolerance to the non-opioid antinociceptive actions of this compound. These results further indicate that cross-tolerance (to morphine) and dependence (increased sensitivity to naltrexone) can occur in the absence of tolerance (to mirfentanil).

Original languageEnglish (US)
Pages (from-to)543-547
Number of pages5
JournalBehavioural Pharmacology
Volume10
Issue number5
StatePublished - 1999
Externally publishedYes

Fingerprint

Morphine
Naltrexone
Ketamine
Morphine Dependence
Columbidae
Fentanyl
mirfentanil
Opioid Analgesics

Keywords

  • Dependence
  • Mirfentanil
  • Morphine
  • Non-opioid
  • Opioid
  • Pigeon
  • Rate-decreasing
  • Tolerance

ASJC Scopus subject areas

  • Pharmacology
  • Neuroscience(all)

Cite this

Daily mirfentanil induces (cross-) tolerance to the rate-decreasing effects of morphine and not mirfentanil. / Gauthier, C. A.; Bagley, J. R.; Brockunier, L. L.; France, Charles P.

In: Behavioural Pharmacology, Vol. 10, No. 5, 1999, p. 543-547.

Research output: Contribution to journalArticle

@article{71307a8dd807409195e6c69b667b1af4,
title = "Daily mirfentanil induces (cross-) tolerance to the rate-decreasing effects of morphine and not mirfentanil",
abstract = "The fentanyl derivative mirfentanil has a novel set of behavioral effects in non-humans including low-efficacy opioid actions and non-opioid antinociceptive actions. This study evaluated the rate decreasing effects of mirfentanil, morphine, naltrexone and ketamine in pigeons both prior to and during a period of chronic treatment with mirfentanil (3.2-17.8 mg/kg/day). Daily treatment with mirfentanil did not modify the rate-decreasing effects of mirfentanil or ketamine; however, daily treatment decreased sensitivity to the rate decreasing effects of morphine and increased sensitivity to naltrexone. These results demonstrate a lack of tolerance to an apparently non-opioid action (rate-decreasing effect) of mirfentanil, which might predict a lack of tolerance to the non-opioid antinociceptive actions of this compound. These results further indicate that cross-tolerance (to morphine) and dependence (increased sensitivity to naltrexone) can occur in the absence of tolerance (to mirfentanil).",
keywords = "Dependence, Mirfentanil, Morphine, Non-opioid, Opioid, Pigeon, Rate-decreasing, Tolerance",
author = "Gauthier, {C. A.} and Bagley, {J. R.} and Brockunier, {L. L.} and France, {Charles P}",
year = "1999",
language = "English (US)",
volume = "10",
pages = "543--547",
journal = "Behavioural Pharmacology",
issn = "0955-8810",
publisher = "Lippincott Williams and Wilkins",
number = "5",

}

TY - JOUR

T1 - Daily mirfentanil induces (cross-) tolerance to the rate-decreasing effects of morphine and not mirfentanil

AU - Gauthier, C. A.

AU - Bagley, J. R.

AU - Brockunier, L. L.

AU - France, Charles P

PY - 1999

Y1 - 1999

N2 - The fentanyl derivative mirfentanil has a novel set of behavioral effects in non-humans including low-efficacy opioid actions and non-opioid antinociceptive actions. This study evaluated the rate decreasing effects of mirfentanil, morphine, naltrexone and ketamine in pigeons both prior to and during a period of chronic treatment with mirfentanil (3.2-17.8 mg/kg/day). Daily treatment with mirfentanil did not modify the rate-decreasing effects of mirfentanil or ketamine; however, daily treatment decreased sensitivity to the rate decreasing effects of morphine and increased sensitivity to naltrexone. These results demonstrate a lack of tolerance to an apparently non-opioid action (rate-decreasing effect) of mirfentanil, which might predict a lack of tolerance to the non-opioid antinociceptive actions of this compound. These results further indicate that cross-tolerance (to morphine) and dependence (increased sensitivity to naltrexone) can occur in the absence of tolerance (to mirfentanil).

AB - The fentanyl derivative mirfentanil has a novel set of behavioral effects in non-humans including low-efficacy opioid actions and non-opioid antinociceptive actions. This study evaluated the rate decreasing effects of mirfentanil, morphine, naltrexone and ketamine in pigeons both prior to and during a period of chronic treatment with mirfentanil (3.2-17.8 mg/kg/day). Daily treatment with mirfentanil did not modify the rate-decreasing effects of mirfentanil or ketamine; however, daily treatment decreased sensitivity to the rate decreasing effects of morphine and increased sensitivity to naltrexone. These results demonstrate a lack of tolerance to an apparently non-opioid action (rate-decreasing effect) of mirfentanil, which might predict a lack of tolerance to the non-opioid antinociceptive actions of this compound. These results further indicate that cross-tolerance (to morphine) and dependence (increased sensitivity to naltrexone) can occur in the absence of tolerance (to mirfentanil).

KW - Dependence

KW - Mirfentanil

KW - Morphine

KW - Non-opioid

KW - Opioid

KW - Pigeon

KW - Rate-decreasing

KW - Tolerance

UR - http://www.scopus.com/inward/record.url?scp=0032860396&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0032860396&partnerID=8YFLogxK

M3 - Article

C2 - 10780260

AN - SCOPUS:0032860396

VL - 10

SP - 543

EP - 547

JO - Behavioural Pharmacology

JF - Behavioural Pharmacology

SN - 0955-8810

IS - 5

ER -