Daily fluctuations of DNA synthesis in the corneas of Rana pipiens

William W. Morgan, Sherwin Mizell

Research output: Contribution to journalArticlepeer-review

1 Scopus citations


1. 1. A diurnal rhythm in DNA synthesis, as indicated by fluctuations in total 3H thymidine uptake, was demonstrated in the corneas of frogs (Rana pipiens). exposed to a 12 : 12 light-dark lighting régime for 2 weeks and then sacrificed in groups of twelve at 2-hr intervals over a 24-hr period. 2. 2. This rhythm was reproducible, appeared to have a periodicity of nearly 24 hr and was correlated with a similar rhythm in mitotic activity in corneas. 3. 3. Evidence is presented which suggests that the lighting régime may be involved in the regulation of this rhythm in DNA synthesis.

Original languageEnglish (US)
Pages (from-to)487-493
Number of pages7
JournalComparative Biochemistry and Physiology -- Part A: Physiology
Issue number2
StatePublished - Oct 1 1971
Externally publishedYes


  • H thymidine
  • cell metabolism
  • cornea
  • Daily rhythm
  • DNA synthesis
  • growth
  • lighting régime
  • Rana pipiens
  • rhythms

ASJC Scopus subject areas

  • Physiology


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