DAI Another Way: Necroptotic Control of Viral Infection

Jason W. Upton, William J. Kaiser

Research output: Contribution to journalComment/debatepeer-review

12 Scopus citations

Abstract

Interrogation of murine cytomegalovirus (MCMV)-encoded cell-death suppressors revealed that necroptosis functions as a trap door to eliminate virally infected cells. This crucial host defense pathway is orchestrated by the sensing of infection by DAI/ZBP-1, engagement of the kinase RIPK3, and subsequent membrane permeablization by the pseudokinase MLKL.

Original languageEnglish (US)
Pages (from-to)290-293
Number of pages4
JournalCell Host and Microbe
Volume21
Issue number3
DOIs
StatePublished - Mar 8 2017

ASJC Scopus subject areas

  • Parasitology
  • Microbiology
  • Virology

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