DAI Another Way: Necroptotic Control of Viral Infection

Jason W. Upton, William Kaiser

Research output: Contribution to journalComment/debate

11 Scopus citations


Interrogation of murine cytomegalovirus (MCMV)-encoded cell-death suppressors revealed that necroptosis functions as a trap door to eliminate virally infected cells. This crucial host defense pathway is orchestrated by the sensing of infection by DAI/ZBP-1, engagement of the kinase RIPK3, and subsequent membrane permeablization by the pseudokinase MLKL.

Original languageEnglish (US)
Pages (from-to)290-293
Number of pages4
JournalCell Host and Microbe
Issue number3
StatePublished - Mar 8 2017

ASJC Scopus subject areas

  • Molecular Biology
  • Immunology and Microbiology(all)
  • Cancer Research

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