D-glucaric acid content of various fruits and vegetables and cholesterol-lowering effects of dietary D-glucarate in the rat

Zbigniew Walaszek; Janusz Szemraj; Malgorzata Hanausek; Alan K. Adams; Ute Sherman

doi:10.1016/0271-5317(96)00045-0

D-glucaric acid content of various fruits and vegetables and cholesterol-lowering effects of dietary D-glucarate in the rat

Zbigniew Walaszek, Janusz Szemraj, Malgorzata Hanausek, Alan K. Adams, Ute Sherman

Research output: Contribution to journal › Article › peer-review

81 Scopus citations

Abstract

The beneficial properties of different vitamins, minerals, and other micronutrients have been studied for quite some time. But only recently has the potential usefulness of D-glucaric acid and its derivatives in disease prevention been demonstrated. D-Glucaric acid is an end product of the D-glucuronic acid pathway in mammals. Its dietary sources include different fruits and vegetables. In the present study, D-glucaric acid content in various fruits and vegetables was found to range from about 0.1 g/kg in grapes and lettuce to about 3.5 g/kg in apples and broccoli. It was also shown that purified diets containing calcium D-glucarate or potassium hydrogen D-glucarate markedly lowered serum levels of cholesterol in female Sprague-Dawley rats. The D-glucarates reduced total serum cholesterol in rats by up to 14% (P<0.05) and lowered LDL-cholesterol by up to 35% (P<0.05), but had no effect on HDL cholesterol. These results provide a starting point for further studies of the mechanism by which D-glucaric acid salts lower serum cholesterol.

Original language	English (US)
Pages (from-to)	673-681
Number of pages	9
Journal	Nutrition Research
Volume	16
Issue number	4
DOIs	https://doi.org/10.1016/0271-5317(96)00045-0
State	Published - Apr 1996
Externally published	Yes

Keywords

Calcium D-Glucarate
D-Glucaric acid
Potassium Hydrogen D-Glucarate
Rats
Serum Cholesterol

ASJC Scopus subject areas

Endocrinology, Diabetes and Metabolism
Endocrinology
Nutrition and Dietetics

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10.1016/0271-5317(96)00045-0

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title = "D-glucaric acid content of various fruits and vegetables and cholesterol-lowering effects of dietary D-glucarate in the rat",

abstract = "The beneficial properties of different vitamins, minerals, and other micronutrients have been studied for quite some time. But only recently has the potential usefulness of D-glucaric acid and its derivatives in disease prevention been demonstrated. D-Glucaric acid is an end product of the D-glucuronic acid pathway in mammals. Its dietary sources include different fruits and vegetables. In the present study, D-glucaric acid content in various fruits and vegetables was found to range from about 0.1 g/kg in grapes and lettuce to about 3.5 g/kg in apples and broccoli. It was also shown that purified diets containing calcium D-glucarate or potassium hydrogen D-glucarate markedly lowered serum levels of cholesterol in female Sprague-Dawley rats. The D-glucarates reduced total serum cholesterol in rats by up to 14% (P<0.05) and lowered LDL-cholesterol by up to 35% (P<0.05), but had no effect on HDL cholesterol. These results provide a starting point for further studies of the mechanism by which D-glucaric acid salts lower serum cholesterol.",

keywords = "Calcium D-Glucarate, D-Glucaric acid, Potassium Hydrogen D-Glucarate, Rats, Serum Cholesterol",

author = "Zbigniew Walaszek and Janusz Szemraj and Malgorzata Hanausek and Adams, {Alan K.} and Ute Sherman",

note = "Funding Information: The excellent technical assistance of Ms. Ana Griffin is greatly appreciated. This research was supported in part by National Institutes of Health Grant CA47342, American Institute for Cancer Research Grant 86A29, and American Cancer Society Special Grant 14.",

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doi = "10.1016/0271-5317(96)00045-0",

language = "English (US)",

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pages = "673--681",

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T1 - D-glucaric acid content of various fruits and vegetables and cholesterol-lowering effects of dietary D-glucarate in the rat

AU - Walaszek, Zbigniew

AU - Szemraj, Janusz

AU - Hanausek, Malgorzata

AU - Adams, Alan K.

AU - Sherman, Ute

N1 - Funding Information: The excellent technical assistance of Ms. Ana Griffin is greatly appreciated. This research was supported in part by National Institutes of Health Grant CA47342, American Institute for Cancer Research Grant 86A29, and American Cancer Society Special Grant 14.

PY - 1996/4

Y1 - 1996/4

N2 - The beneficial properties of different vitamins, minerals, and other micronutrients have been studied for quite some time. But only recently has the potential usefulness of D-glucaric acid and its derivatives in disease prevention been demonstrated. D-Glucaric acid is an end product of the D-glucuronic acid pathway in mammals. Its dietary sources include different fruits and vegetables. In the present study, D-glucaric acid content in various fruits and vegetables was found to range from about 0.1 g/kg in grapes and lettuce to about 3.5 g/kg in apples and broccoli. It was also shown that purified diets containing calcium D-glucarate or potassium hydrogen D-glucarate markedly lowered serum levels of cholesterol in female Sprague-Dawley rats. The D-glucarates reduced total serum cholesterol in rats by up to 14% (P<0.05) and lowered LDL-cholesterol by up to 35% (P<0.05), but had no effect on HDL cholesterol. These results provide a starting point for further studies of the mechanism by which D-glucaric acid salts lower serum cholesterol.

AB - The beneficial properties of different vitamins, minerals, and other micronutrients have been studied for quite some time. But only recently has the potential usefulness of D-glucaric acid and its derivatives in disease prevention been demonstrated. D-Glucaric acid is an end product of the D-glucuronic acid pathway in mammals. Its dietary sources include different fruits and vegetables. In the present study, D-glucaric acid content in various fruits and vegetables was found to range from about 0.1 g/kg in grapes and lettuce to about 3.5 g/kg in apples and broccoli. It was also shown that purified diets containing calcium D-glucarate or potassium hydrogen D-glucarate markedly lowered serum levels of cholesterol in female Sprague-Dawley rats. The D-glucarates reduced total serum cholesterol in rats by up to 14% (P<0.05) and lowered LDL-cholesterol by up to 35% (P<0.05), but had no effect on HDL cholesterol. These results provide a starting point for further studies of the mechanism by which D-glucaric acid salts lower serum cholesterol.

KW - Calcium D-Glucarate

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KW - Potassium Hydrogen D-Glucarate

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D-glucaric acid content of various fruits and vegetables and cholesterol-lowering effects of dietary D-glucarate in the rat

Abstract

Keywords

ASJC Scopus subject areas

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