Cytotoxicity in cultured RPE: A comparative study between continuous wave and mode-locked lasers

Michael L. Denton, Debbie M. Eikum, David J. Stolarski, Gary D. Noojin, Robert J. Thomas, Randolph D. Glickman, Benjamin A. Rockwell

Research output: Chapter in Book/Report/Conference proceedingConference contribution

2 Scopus citations

Abstract

We have previously shown that minimum visible lesions (MVL) generated in vivo by exposures at threshold energies are not ophthalmoscopically visible at one hour, but become visible 24 hours post-exposure. Our preliminary studies toward understanding this phenomenon at the molecular level are presented. We provide threshold data relating cytotoxicity with energy for acute laser exposures in cultured retinal pigment epithelial cells. Rapid loss of cell viability is used as an initial endpoint of analysis. Comparisons of damage efficiency for continuous wave and mode-locked lasers are presented.

Original languageEnglish (US)
Title of host publicationProceedings of SPIE - The International Society for Optical Engineering
EditorsS.L. Jacques, D.D. Duncan, S.J. Kirkpatrick, A. Kriete
Pages156-160
Number of pages5
Volume4617
DOIs
StatePublished - 2002
EventLaser Tissue Interaction XIII: Photochemical, Photothermal and Photomechanical - San Jose, CA, United States
Duration: Jan 20 2002Jan 23 2002

Other

OtherLaser Tissue Interaction XIII: Photochemical, Photothermal and Photomechanical
CountryUnited States
CitySan Jose, CA
Period1/20/021/23/02

Keywords

  • Cytotoxicity
  • Fluorescence microscopy
  • Mode-locked
  • RPE cells

ASJC Scopus subject areas

  • Electrical and Electronic Engineering
  • Condensed Matter Physics

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    Denton, M. L., Eikum, D. M., Stolarski, D. J., Noojin, G. D., Thomas, R. J., Glickman, R. D., & Rockwell, B. A. (2002). Cytotoxicity in cultured RPE: A comparative study between continuous wave and mode-locked lasers. In S. L. Jacques, D. D. Duncan, S. J. Kirkpatrick, & A. Kriete (Eds.), Proceedings of SPIE - The International Society for Optical Engineering (Vol. 4617, pp. 156-160) https://doi.org/10.1117/12.472519