Cytomorphologic features of low-grade endometrial stromal sarcoma

Maria Luisa Policarpio-Nicolas, Helen P. Cathro, Sarah E. Kerr, Edward B. Stelow

Research output: Contribution to journalArticle

19 Scopus citations


Endometrial stromal sarcomas are uncommon tumors of the uterus, and the cytologic features have only been reported in a number of case reports that mostly discuss the features of higher grade undifferentiated sarcomas. This article discusses the cytologic features of a large series of low-grade endometrial stromal sarcomas (ESSs) sampled by a variety of methods. We reviewed our histologic files for all confirmed cases of low-grade ESS, and followed this by a computerized search for any corresponding cytologic specimens. We identified 12 Papanicolaou tests and 9 nongynecologic specimens. Most cases showed moderate to marked cellularity with a combination of single cells and stromal fragments. Blood vessels, interspersed between the clusters of stromal cells, were seen in 15 cases; 4 of these had supporting hyaline matrix. The cells were predominantly spindle shaped with scant to moderate cytoplasm, round to ovoid nuclei, and fine chromatin. Mitotic figures and nucleoli were rare. Most cases had a clean background.

Original languageEnglish (US)
Pages (from-to)265-271
Number of pages7
JournalAmerican Journal of Clinical Pathology
Issue number2
StatePublished - Aug 1 2007



  • Cytology
  • Endometrial stromal sarcoma
  • Fine-needle aspiration
  • Gynecologic
  • Low grade
  • Nongynecologic
  • Papanicolaou test

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

Policarpio-Nicolas, M. L., Cathro, H. P., Kerr, S. E., & Stelow, E. B. (2007). Cytomorphologic features of low-grade endometrial stromal sarcoma. American Journal of Clinical Pathology, 128(2), 265-271.