Cytomegaloviral hypophysitis in a simian immunodeficiency virus-infected rhesus macaque (Macacca mulatta)

Melissa R. Berg, Michael A. Owston, Marie Claire Gauduin, Basel T. Assaf, Anne D. Lewis, Edward J. Dick

    Research output: Contribution to journalArticlepeer-review

    Abstract

    Rhesus macaques experimentally infected with Simian Immunodeficiency Virus (SIV) experience immunosuppression and often opportunistic infection. Among the most common opportunistic infections are rhesus cytomegalovirus (RhCMV), a ubiquitous betaherpesvirus that undergoes continuous low-level replication in immunocompetent monkeys. Upon SIV-mediated immunodeficiency, RhCMV reactivates and results in lesions in numerous organ systems including the nervous and reproductive systems. We report the first case of cytomegaloviral hypophysitis in a SIV-immunocompromised rhesus macaque.

    Original languageEnglish (US)
    Pages (from-to)364-367
    Number of pages4
    JournalJournal of medical primatology
    Volume46
    Issue number6
    DOIs
    StatePublished - Dec 2017

    Keywords

    • cytomegalovirus
    • inclusions
    • intra-cytoplasmic
    • intranuclear
    • model
    • non-human primate
    • pituitary
    • viral

    ASJC Scopus subject areas

    • Animal Science and Zoology
    • veterinary(all)

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