Cytologic atypia associated with microglandular hyperplasia

Philip T Valente, H. D. Schantz, M. Schultz

Research output: Contribution to journalArticle

33 Citations (Scopus)

Abstract

Although it has long been known that microglandular hyperplasia (MGH) may be associated with cytologic atypia in cervical smears, the cytomorphology of MGH has not been described in great detail. To clarify its cytomorphology, Pap smears obtained from biopsy proven cases of MGH over a 3-yr period were reviewed. Of 122 smears containing endocervical cells, 34 (28%) showed striking glandular abnormalities. In two cases, adenocarcinoma and adenocarcinoma in situ were falsely suggested and a high grade squamous intraepithelial lesion (HGSIL-CIN III) was not confirmed in a conization specimen which showed only low grade SIL and MGH. Review of six cytologic diagnoses of HGSIL (CIN III) unconfirmed on biopsy suggested overcalls related to MGH related atypia in five. Cytologic features of MGH, therefore, may occasionally result in erroneous interpretations of HGSIL as well as glandular neoplasia. Although these changes may be striking, comparison with glandular atypia not associated with MGH shows that they are not entirely specific.

Original languageEnglish (US)
Pages (from-to)326-331
Number of pages6
JournalDiagnostic Cytopathology
Volume10
Issue number4
DOIs
StatePublished - 1994

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Hyperplasia
Conization
Biopsy
Papanicolaou Test
Vaginal Smears
Adenocarcinoma
Neoplasms

Keywords

  • Cervicovaginal smears
  • Glandular atypia
  • Oral contraceptives

ASJC Scopus subject areas

  • Anatomy

Cite this

Cytologic atypia associated with microglandular hyperplasia. / Valente, Philip T; Schantz, H. D.; Schultz, M.

In: Diagnostic Cytopathology, Vol. 10, No. 4, 1994, p. 326-331.

Research output: Contribution to journalArticle

Valente, Philip T ; Schantz, H. D. ; Schultz, M. / Cytologic atypia associated with microglandular hyperplasia. In: Diagnostic Cytopathology. 1994 ; Vol. 10, No. 4. pp. 326-331.
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