Cytokines in bipolar disorder: Paving the way for neuroprogression

Izabela Guimarães Barbosa, Moisés Evandro Bauer, Rodrigo MacHado-Vieira, Antonio Lucio Teixeira

Research output: Contribution to journalReview articlepeer-review

123 Scopus citations

Abstract

Bipolar disorder (BD) is a severe, chronic, and recurrent psychiatric illness. It has been associated with high prevalence of medical comorbidities and cognitive impairment. Its neurobiology is not completely understood, but recent evidence has shown a wide range of immune changes. Cytokines are proteins involved in the regulation and the orchestration of the immune response. We performed a review on the involvement of cytokines in BD. We also discuss the cytokines involvement in the neuroprogression of BD. It has been demonstrated that increased expression of cytokines in the central nervous system in postmortem studies is in line with the elevated circulating levels of proinflammatory cytokines in BD patients. The proinflammatory profile and the immune imbalance in BD might be regarded as potential targets to the development of new therapeutic strategies.

Original languageEnglish (US)
Article number360481
JournalNeural Plasticity
Volume2014
DOIs
StatePublished - 2014
Externally publishedYes

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

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