Cytogenetics of melanoma and nonmelanoma skin cancer.

Melanie A. Carless, Lyn R. Griffiths

    Research output: Contribution to journalReview article

    7 Scopus citations

    Abstract

    Cytogenetic analysis of melanoma and nonmelanoma skin cancers has revealed recurrent aberrations, the frequency of which is reflective of malignant potential. Highly aberrant karyotypes are seen in melanoma, squamous cell carcinoma, actinic keratosis, Merkel cell carcinoma and cutaneous lymphomas with more stable karyotypes seen in basal cell carcinoma, keratoacanthoma, Bowen's disease and dermatofibrosarcoma protuberans. Some aberrations are common among a number of skin cancer types including rearrangements and numerical abnormalities of chromosome 1, -3p, +3q, partial or entire trisomy 6, trisomy 7, +8q, -9p, +9q, partial or entire loss of chromosome 10, -17p, +17q and partial or entire gain of chromosome 20. Combination of cytogenetic analysis with other molecular genetic techniques has enabled the identification of not only aberrant chromosomal regions, but also the genes that contribute to a malignant phenotype. This review provides a comprehensive summary of the pertinent cytogenetic aberrations associated with a variety of melanoma and nonmelanoma skin cancers.

    Original languageEnglish (US)
    Pages (from-to)160-181
    Number of pages22
    JournalAdvances in experimental medicine and biology
    Volume810
    StatePublished - 2014

    ASJC Scopus subject areas

    • Biochemistry, Genetics and Molecular Biology(all)

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