Abstract
The cytogenetics of hepatoblastoma demonstrate recurring events which include whole chromosome trisomies, most commonly trisomy of chromosome 2, 8, or 10. In addition, unbalanced translocations involving a breakpoint on the proximal short arm of chromosome 1 are observed which result in a duplication of the long arm of chromosome 1q. The most commonly involved reciprocal chromosomal arm is 4q, although the reciprocal chromosome is highly variable and always results in a loss of chromosomal material. The full significance of these chromosomal changes has yet to be confirmed in large studies, however a suggestion of an association of duplication of regions of 2q with a poor prognosis. A rare sub-type of hepatoblastoma, known as the small cell undifferentiated variant, is associated with deletion or translocation of 22q, the locus of the rhabdoid tumor gene, SMARCB1.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1287-1292 |
| Number of pages | 6 |
| Journal | Frontiers in Bioscience - Elite |
| Volume | 4 E |
| Issue number | 4 |
| State | Published - Jan 1 2012 |
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Keywords
- Hepatoblastoma
- Karyotype
- Liver
- Trisomy
- Tumor
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)
- Immunology and Microbiology(all)
Cite this
Cytogenetics of hepatoblastoma. / Tomlinson, Gail.
In: Frontiers in Bioscience - Elite, Vol. 4 E, No. 4, 01.01.2012, p. 1287-1292.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Cytogenetics of hepatoblastoma
AU - Tomlinson, Gail
PY - 2012/1/1
Y1 - 2012/1/1
N2 - The cytogenetics of hepatoblastoma demonstrate recurring events which include whole chromosome trisomies, most commonly trisomy of chromosome 2, 8, or 10. In addition, unbalanced translocations involving a breakpoint on the proximal short arm of chromosome 1 are observed which result in a duplication of the long arm of chromosome 1q. The most commonly involved reciprocal chromosomal arm is 4q, although the reciprocal chromosome is highly variable and always results in a loss of chromosomal material. The full significance of these chromosomal changes has yet to be confirmed in large studies, however a suggestion of an association of duplication of regions of 2q with a poor prognosis. A rare sub-type of hepatoblastoma, known as the small cell undifferentiated variant, is associated with deletion or translocation of 22q, the locus of the rhabdoid tumor gene, SMARCB1.
AB - The cytogenetics of hepatoblastoma demonstrate recurring events which include whole chromosome trisomies, most commonly trisomy of chromosome 2, 8, or 10. In addition, unbalanced translocations involving a breakpoint on the proximal short arm of chromosome 1 are observed which result in a duplication of the long arm of chromosome 1q. The most commonly involved reciprocal chromosomal arm is 4q, although the reciprocal chromosome is highly variable and always results in a loss of chromosomal material. The full significance of these chromosomal changes has yet to be confirmed in large studies, however a suggestion of an association of duplication of regions of 2q with a poor prognosis. A rare sub-type of hepatoblastoma, known as the small cell undifferentiated variant, is associated with deletion or translocation of 22q, the locus of the rhabdoid tumor gene, SMARCB1.
KW - Hepatoblastoma
KW - Karyotype
KW - Liver
KW - Trisomy
KW - Tumor
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UR - http://www.scopus.com/inward/citedby.url?scp=84883595650&partnerID=8YFLogxK
M3 - Article
C2 - 22201954
AN - SCOPUS:84883595650
VL - 4 E
SP - 1287
EP - 1292
JO - Frontiers in Bioscience - Elite
JF - Frontiers in Bioscience - Elite
SN - 1945-0494
IS - 4
ER -