A renal cell carcinoma from a 17-month-old boy with a history of maternal hydrocarbon exposure was found to have a 46,Y,t(X;17)(p11.2;q25) karyotype. Although this translocation has not previously been reported, other translocations involving Xp11.2 have been described, suggesting that this may represent a non-random breakpoint involved in the pathogenesis of childhood renal cell carcinoma. Both chromosomes 3 in the tumor were normal by both karyotype and RFLP analysis.
|Original language||English (US)|
|Number of pages||7|
|Journal||Cancer Genetics and Cytogenetics|
|State||Published - Nov 1991|
ASJC Scopus subject areas
- Molecular Biology
- Cancer Research