Cytogenetics of a renal cell carcinoma in a 17-month-old child. Evidence for Xp11.2 as a recurring breakpoint

Gail E. Tomlinson; Perry D. Nisen; Charles F. Timmons; Nancy R. Schneider

doi:10.1016/0165-4608(91)90184-V

Cytogenetics of a renal cell carcinoma in a 17-month-old child. Evidence for Xp11.2 as a recurring breakpoint

Gail E. Tomlinson, Perry D. Nisen, Charles F. Timmons, Nancy R. Schneider

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Abstract

A renal cell carcinoma from a 17-month-old boy with a history of maternal hydrocarbon exposure was found to have a 46,Y,t(X;17)(p11.2;q25) karyotype. Although this translocation has not previously been reported, other translocations involving Xp11.2 have been described, suggesting that this may represent a non-random breakpoint involved in the pathogenesis of childhood renal cell carcinoma. Both chromosomes 3 in the tumor were normal by both karyotype and RFLP analysis.

Original language	English (US)
Pages (from-to)	11-17
Number of pages	7
Journal	Cancer Genetics and Cytogenetics
Volume	57
Issue number	1
DOIs	https://doi.org/10.1016/0165-4608(91)90184-V
State	Published - Nov 1991
Externally published	Yes

ASJC Scopus subject areas

Genetics
Molecular Biology
Cancer Research

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title = "Cytogenetics of a renal cell carcinoma in a 17-month-old child. Evidence for Xp11.2 as a recurring breakpoint",

abstract = "A renal cell carcinoma from a 17-month-old boy with a history of maternal hydrocarbon exposure was found to have a 46,Y,t(X;17)(p11.2;q25) karyotype. Although this translocation has not previously been reported, other translocations involving Xp11.2 have been described, suggesting that this may represent a non-random breakpoint involved in the pathogenesis of childhood renal cell carcinoma. Both chromosomes 3 in the tumor were normal by both karyotype and RFLP analysis.",

author = "Tomlinson, {Gail E.} and Nisen, {Perry D.} and Timmons, {Charles F.} and Schneider, {Nancy R.}",

note = "Funding Information: This work was supported in part by NIH Training Grant #CA09640 and the Children's Cancer Fund of Dallas.",

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AU - Nisen, Perry D.

AU - Timmons, Charles F.

AU - Schneider, Nancy R.

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PY - 1991/11

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AB - A renal cell carcinoma from a 17-month-old boy with a history of maternal hydrocarbon exposure was found to have a 46,Y,t(X;17)(p11.2;q25) karyotype. Although this translocation has not previously been reported, other translocations involving Xp11.2 have been described, suggesting that this may represent a non-random breakpoint involved in the pathogenesis of childhood renal cell carcinoma. Both chromosomes 3 in the tumor were normal by both karyotype and RFLP analysis.

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Cytogenetics of a renal cell carcinoma in a 17-month-old child. Evidence for Xp11.2 as a recurring breakpoint

Abstract

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