Cytogenetics of a renal cell carcinoma in a 17-month-old child. Evidence for Xp11.2 as a recurring breakpoint

Gail E. Tomlinson, Perry D. Nisen, Charles F. Timmons, Nancy R. Schneider

Research output: Contribution to journalArticlepeer-review

81 Scopus citations

Abstract

A renal cell carcinoma from a 17-month-old boy with a history of maternal hydrocarbon exposure was found to have a 46,Y,t(X;17)(p11.2;q25) karyotype. Although this translocation has not previously been reported, other translocations involving Xp11.2 have been described, suggesting that this may represent a non-random breakpoint involved in the pathogenesis of childhood renal cell carcinoma. Both chromosomes 3 in the tumor were normal by both karyotype and RFLP analysis.

Original languageEnglish (US)
Pages (from-to)11-17
Number of pages7
JournalCancer Genetics and Cytogenetics
Volume57
Issue number1
DOIs
StatePublished - Nov 1991

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics
  • Cancer Research

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