Cytochromes P450 - A family of proteins and scientists-understanding their relationships

Bettie Sue Masters, Christopher C. Marohnic

Research output: Contribution to journalReview articlepeer-review

23 Scopus citations

Abstract

The unifying thread of this review involves NADPH-cytochrome P450 reductase (CYPOR), the microsomal enzyme responsible for transferring electrons to cytochromes P450, as well as several other monooxygenase systems, a lifelong interest of the corresponding author. The intersection of her research with that of Dr. David Kupfer, their resulting collaboration, and the beginning of a long-standing study of fatty acid- and eicosanoid-metabolizing cytochromes P450 (CYP4A gene subfamily), including the role of cytochrome b5, will be reported. The culmination of this interest now involves purification and characterization of the human mutants of CYPOR that have been implicated in pathologies, such as Antley-Bixler syndrome.

Original languageEnglish (US)
Pages (from-to)209-225
Number of pages17
JournalDrug Metabolism Reviews
Volume38
Issue number1-2
DOIs
StatePublished - May 24 2006

Keywords

  • Antley-Bixler syndrome
  • Arachidonic acid
  • CYP4A gene subfamily
  • CYPOR
  • CYPOR polymorphisms
  • Cytochrome b
  • Eicosanoids
  • Fatty Acids
  • NADPH-cytochrome P450 reductase
  • Prostaglandins

ASJC Scopus subject areas

  • Pharmacology, Toxicology and Pharmaceutics(all)
  • Pharmacology (medical)

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