Cyclosporine-induced hypertension: Evidence for maintained baroreflex circulatory control

D. Lucini, R. V. Milani, H. O. Ventura, M. R. Mehra, F. H. Messerli, Joseph P Murgo, F. Regenstein, B. Copley, A. Malliani, M. Pagani

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Background: The clinical use of cyclosporine as an immunosuppressive agent enhanced long-term survival in transplant recipients at the expense of a high incidence of induced hypertension. Altered neurovegetative (autonomic) cardiovascular control is suspected as a mechanism of this form of hypertension. Methods: Spectral analysis of systolic arterial pressure and R- R interval variability (electrocardiographic recordings) were performed, and the index α of baroreflex gain was computed in four groups of subjects matched for age: 13 orthotopic heart transplant recipients; 13 solid organ transplant recipients; 13 patients with essential hypertension; and 18 control subjects with normal blood pressure. All but the control subjects were treated with similar dihydropyridine calcium entry blockers. Heart and solid organ transplant recipients also received cyclosporine. Results: R-R variance was lowest in the heart transplant recipients. The spectral profile of R-R interval was suggestive of sympathetic predominance in the patients withhypertension, but not in the solid organ transplant recipients or the control subjects. Systolic blood pressure variability and low frequency component (a marker of sympathetic vasomotor modulation) were similar in the four groups. The index α was 1.8 ± 2.2 in heart transplant recipients, 11.7 ± 6.6 in solid organ transplant recipients, 7.3 ± 3.6 in patients with hypertension, and 13.5 ± 6.4 msec/mm Hg in control subjects (p = 0.0001). Conclusions: These data indicate that (1) cyclosporine-induced hypertension in heart transplant recipients is associated with a loss of baroreflex function as a result of cardiac denervation-related uncoupling; (2) compared with patients with hypertension, organ transplant recipients with hypertension demonstrated a maintained baroreflex function as indicated by a lack of reduction of the index α; (3) baroreflex heart rate control in dihydropyridine-treated cyclosporine-induced hypertension is well maintained.

Original languageEnglish (US)
Pages (from-to)615-620
Number of pages6
JournalJournal of Heart and Lung Transplantation
Volume16
Issue number6
StatePublished - 1997
Externally publishedYes

Fingerprint

Baroreflex
Cyclosporine
Hypertension
Transplants
Blood Pressure
Transplant Recipients
Denervation
Immunosuppressive Agents
Arterial Pressure
Research Design
Heart Rate
Calcium
Survival

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Surgery
  • Transplantation

Cite this

Lucini, D., Milani, R. V., Ventura, H. O., Mehra, M. R., Messerli, F. H., Murgo, J. P., ... Pagani, M. (1997). Cyclosporine-induced hypertension: Evidence for maintained baroreflex circulatory control. Journal of Heart and Lung Transplantation, 16(6), 615-620.

Cyclosporine-induced hypertension : Evidence for maintained baroreflex circulatory control. / Lucini, D.; Milani, R. V.; Ventura, H. O.; Mehra, M. R.; Messerli, F. H.; Murgo, Joseph P; Regenstein, F.; Copley, B.; Malliani, A.; Pagani, M.

In: Journal of Heart and Lung Transplantation, Vol. 16, No. 6, 1997, p. 615-620.

Research output: Contribution to journalArticle

Lucini, D, Milani, RV, Ventura, HO, Mehra, MR, Messerli, FH, Murgo, JP, Regenstein, F, Copley, B, Malliani, A & Pagani, M 1997, 'Cyclosporine-induced hypertension: Evidence for maintained baroreflex circulatory control', Journal of Heart and Lung Transplantation, vol. 16, no. 6, pp. 615-620.
Lucini D, Milani RV, Ventura HO, Mehra MR, Messerli FH, Murgo JP et al. Cyclosporine-induced hypertension: Evidence for maintained baroreflex circulatory control. Journal of Heart and Lung Transplantation. 1997;16(6):615-620.
Lucini, D. ; Milani, R. V. ; Ventura, H. O. ; Mehra, M. R. ; Messerli, F. H. ; Murgo, Joseph P ; Regenstein, F. ; Copley, B. ; Malliani, A. ; Pagani, M. / Cyclosporine-induced hypertension : Evidence for maintained baroreflex circulatory control. In: Journal of Heart and Lung Transplantation. 1997 ; Vol. 16, No. 6. pp. 615-620.
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abstract = "Background: The clinical use of cyclosporine as an immunosuppressive agent enhanced long-term survival in transplant recipients at the expense of a high incidence of induced hypertension. Altered neurovegetative (autonomic) cardiovascular control is suspected as a mechanism of this form of hypertension. Methods: Spectral analysis of systolic arterial pressure and R- R interval variability (electrocardiographic recordings) were performed, and the index α of baroreflex gain was computed in four groups of subjects matched for age: 13 orthotopic heart transplant recipients; 13 solid organ transplant recipients; 13 patients with essential hypertension; and 18 control subjects with normal blood pressure. All but the control subjects were treated with similar dihydropyridine calcium entry blockers. Heart and solid organ transplant recipients also received cyclosporine. Results: R-R variance was lowest in the heart transplant recipients. The spectral profile of R-R interval was suggestive of sympathetic predominance in the patients withhypertension, but not in the solid organ transplant recipients or the control subjects. Systolic blood pressure variability and low frequency component (a marker of sympathetic vasomotor modulation) were similar in the four groups. The index α was 1.8 ± 2.2 in heart transplant recipients, 11.7 ± 6.6 in solid organ transplant recipients, 7.3 ± 3.6 in patients with hypertension, and 13.5 ± 6.4 msec/mm Hg in control subjects (p = 0.0001). Conclusions: These data indicate that (1) cyclosporine-induced hypertension in heart transplant recipients is associated with a loss of baroreflex function as a result of cardiac denervation-related uncoupling; (2) compared with patients with hypertension, organ transplant recipients with hypertension demonstrated a maintained baroreflex function as indicated by a lack of reduction of the index α; (3) baroreflex heart rate control in dihydropyridine-treated cyclosporine-induced hypertension is well maintained.",
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T2 - Evidence for maintained baroreflex circulatory control

AU - Lucini, D.

AU - Milani, R. V.

AU - Ventura, H. O.

AU - Mehra, M. R.

AU - Messerli, F. H.

AU - Murgo, Joseph P

AU - Regenstein, F.

AU - Copley, B.

AU - Malliani, A.

AU - Pagani, M.

PY - 1997

Y1 - 1997

N2 - Background: The clinical use of cyclosporine as an immunosuppressive agent enhanced long-term survival in transplant recipients at the expense of a high incidence of induced hypertension. Altered neurovegetative (autonomic) cardiovascular control is suspected as a mechanism of this form of hypertension. Methods: Spectral analysis of systolic arterial pressure and R- R interval variability (electrocardiographic recordings) were performed, and the index α of baroreflex gain was computed in four groups of subjects matched for age: 13 orthotopic heart transplant recipients; 13 solid organ transplant recipients; 13 patients with essential hypertension; and 18 control subjects with normal blood pressure. All but the control subjects were treated with similar dihydropyridine calcium entry blockers. Heart and solid organ transplant recipients also received cyclosporine. Results: R-R variance was lowest in the heart transplant recipients. The spectral profile of R-R interval was suggestive of sympathetic predominance in the patients withhypertension, but not in the solid organ transplant recipients or the control subjects. Systolic blood pressure variability and low frequency component (a marker of sympathetic vasomotor modulation) were similar in the four groups. The index α was 1.8 ± 2.2 in heart transplant recipients, 11.7 ± 6.6 in solid organ transplant recipients, 7.3 ± 3.6 in patients with hypertension, and 13.5 ± 6.4 msec/mm Hg in control subjects (p = 0.0001). Conclusions: These data indicate that (1) cyclosporine-induced hypertension in heart transplant recipients is associated with a loss of baroreflex function as a result of cardiac denervation-related uncoupling; (2) compared with patients with hypertension, organ transplant recipients with hypertension demonstrated a maintained baroreflex function as indicated by a lack of reduction of the index α; (3) baroreflex heart rate control in dihydropyridine-treated cyclosporine-induced hypertension is well maintained.

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