Cyclosporine for SJS/TEN: A case series and review of the literature

Drew Reese, J. Scott Henning, Kyle Rockers, Denise Ladd, Robert Gilson

Research output: Contribution to journalArticlepeer-review

58 Scopus citations


Clear guidelines for the treatment of Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are lacking due to its infrequency and the absence of large controlled studies. Systemic corticosteroids and intravenous immunoglobulin (IVIG) have received considerable attention, though reports of the use of these agents have demonstrated mixed success rates in improving morbidity and mortality from SJS/TEN. We present a case series of 4 patients with SJS/TEN who rapidly responded to treatment with cyclosporin A (CsA). We discuss the proposed mechanism of action and the rationale for the use of cyclosporin based on the currently understood pathophysiologic mechanism of TEN.

Original languageEnglish (US)
Pages (from-to)24-29
Number of pages6
Issue number1
StatePublished - Jan 2011
Externally publishedYes

ASJC Scopus subject areas

  • General Medicine


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