Cyclosporin immunosuppression as the possible cause of AIDS

K. W. Sell, T. Folks, K. J. Kwon-Chung, J. Coligan, W. L. Maloy

Research output: Contribution to journalArticle

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Abstract

Our examination of AIDS plasma by high-performance liquid chromatography has shown the presence of CyAIDS in four of four patients studied. One of these was the same person from whom fungi were isolated. The level of CyAIDS compound was estimated to exceed 1000 ng per milliliter in one patient, and levels above 40 ng per milliliter were detected in the other three. Two normal non-AIDS control blood samples did not show high levels of cyclosporin-like peaks. Although the isolates of T. crustaceus were cultured from monocytes, it seems unlikely that this is the primary source of infection in AIDS. Nevertheless, transmission of the fungus from one person to another through a needle stick or through blood components may be possible.

Original languageEnglish (US)
Pages (from-to)1065-1067
Number of pages3
JournalNew England Journal of Medicine
Volume309
Issue number17
StatePublished - 1983
Externally publishedYes

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Immunosuppression
Cyclosporine
Acquired Immunodeficiency Syndrome
Fungi
Needlestick Injuries
Monocytes
High Pressure Liquid Chromatography
Infection
cyclosporin-like substance

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Sell, K. W., Folks, T., Kwon-Chung, K. J., Coligan, J., & Maloy, W. L. (1983). Cyclosporin immunosuppression as the possible cause of AIDS. New England Journal of Medicine, 309(17), 1065-1067.

Cyclosporin immunosuppression as the possible cause of AIDS. / Sell, K. W.; Folks, T.; Kwon-Chung, K. J.; Coligan, J.; Maloy, W. L.

In: New England Journal of Medicine, Vol. 309, No. 17, 1983, p. 1065-1067.

Research output: Contribution to journalArticle

Sell, KW, Folks, T, Kwon-Chung, KJ, Coligan, J & Maloy, WL 1983, 'Cyclosporin immunosuppression as the possible cause of AIDS', New England Journal of Medicine, vol. 309, no. 17, pp. 1065-1067.
Sell KW, Folks T, Kwon-Chung KJ, Coligan J, Maloy WL. Cyclosporin immunosuppression as the possible cause of AIDS. New England Journal of Medicine. 1983;309(17):1065-1067.
Sell, K. W. ; Folks, T. ; Kwon-Chung, K. J. ; Coligan, J. ; Maloy, W. L. / Cyclosporin immunosuppression as the possible cause of AIDS. In: New England Journal of Medicine. 1983 ; Vol. 309, No. 17. pp. 1065-1067.
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