Cyclic pressure affects osteoblast functions pertinent to osteogenesis

Jiro Nagatomi, Bernard P. Arulanandam, Dennis W. Metzger, Alain Meunier, Rena Bizios

Research output: Contribution to journalConference articlepeer-review


Exposure of osteoblasts to cyclic pressure was studied and cellular/molecular responses of functions that were pertinent to new bone formation were monitored. It was found that exposure to cyclic pressure for one hour daily for up to 19 consecutive days induced specific osteoblast responses such as enhanced mRNA expression of alkaline phosphatase. The results provided insight into the cellular/molecular level mechanism that correlated mechanical loading on the skeleton and bone homeostasis.

Original languageEnglish (US)
Pages (from-to)195-196
Number of pages2
JournalAmerican Society of Mechanical Engineers, Bioengineering Division (Publication) BED
StatePublished - 2001
Externally publishedYes
EventProceedings of the 2001 Bioengineering Conference - Snowbird, UT, United States
Duration: Jun 27 2001Jul 1 2001

ASJC Scopus subject areas

  • Engineering(all)


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