Cyanide antidotes

Patrick C. Ng; Joseph K. Maddry; Vikhyat S. Bebarta

doi:10.1016/B978-0-12-822218-8.00034-X

Cyanide antidotes

Patrick C. Ng, Joseph K. Maddry, Vikhyat S. Bebarta

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Abstract

Cyanide is a potentially deadly chemical. Its lethality has been demonstrated in suicide, homicide, industrial exposures, iatrogenic, and occupational exposures worldwide. Antidote development has focused on two main therapeutic targets: (1) binding cyanide directly and (2) detoxifying cyanide by converting it to a relatively less toxic compound. The history of antidote development for cyanide is discussed.

Original language	English (US)
Title of host publication	History of Modern Clinical Toxicology
Publisher	Elsevier
Pages	279-286
Number of pages	8
ISBN (Electronic)	9780128222188
ISBN (Print)	9780128222195
DOIs	https://doi.org/10.1016/B978-0-12-822218-8.00034-X
State	Published - Jan 1 2021
Externally published	Yes

Keywords

Cobinamide
Cyanide
Dimethyl trisulfide
Hydroxocobalamin
Methemoglobinemia
Methylene blue
Poisoning
Sodium thiosulfate

ASJC Scopus subject areas

General Medicine

Access to Document

10.1016/B978-0-12-822218-8.00034-X

Cite this

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abstract = "Cyanide is a potentially deadly chemical. Its lethality has been demonstrated in suicide, homicide, industrial exposures, iatrogenic, and occupational exposures worldwide. Antidote development has focused on two main therapeutic targets: (1) binding cyanide directly and (2) detoxifying cyanide by converting it to a relatively less toxic compound. The history of antidote development for cyanide is discussed.",

keywords = "Cobinamide, Cyanide, Dimethyl trisulfide, Hydroxocobalamin, Methemoglobinemia, Methylene blue, Poisoning, Sodium thiosulfate",

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AU - Maddry, Joseph K.

AU - Bebarta, Vikhyat S.

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N2 - Cyanide is a potentially deadly chemical. Its lethality has been demonstrated in suicide, homicide, industrial exposures, iatrogenic, and occupational exposures worldwide. Antidote development has focused on two main therapeutic targets: (1) binding cyanide directly and (2) detoxifying cyanide by converting it to a relatively less toxic compound. The history of antidote development for cyanide is discussed.

AB - Cyanide is a potentially deadly chemical. Its lethality has been demonstrated in suicide, homicide, industrial exposures, iatrogenic, and occupational exposures worldwide. Antidote development has focused on two main therapeutic targets: (1) binding cyanide directly and (2) detoxifying cyanide by converting it to a relatively less toxic compound. The history of antidote development for cyanide is discussed.

KW - Cobinamide

KW - Cyanide

KW - Dimethyl trisulfide

KW - Hydroxocobalamin

KW - Methemoglobinemia

KW - Methylene blue

KW - Poisoning

KW - Sodium thiosulfate

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DO - 10.1016/B978-0-12-822218-8.00034-X

M3 - Chapter

AN - SCOPUS:85139368706

SN - 9780128222195

SP - 279

EP - 286

BT - History of Modern Clinical Toxicology

PB - Elsevier

ER -

Cyanide antidotes

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

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