Abstract
Resident T cells in barrier tissues are important in protecting against foreign agents but can also contribute to inflammatory diseases if dysregulated. How T cell homeostasis is maintained in barrier tissues is still poorly understood. We report that resident CD8+ T cells directly support maintenance of regulatory T cells (Tregs) in the skin to promote immune homeostasis. Impaired establishment of resident CD8+ T cells caused by knockout of the skin-homing chemokine receptor CCR10 resulted in an altered balance of resident Tregs and CD4+ effector T cells in the skin and overreactive inflammatory responses to cutaneous stimulations. Furthermore, B7.2 expressed on skin CD8+ T cells supports the survival of Tregs, likely through interaction with its receptor CTLA-4, which is highly expressed on skin Tregs. Our findings provide novel insights into T cell homeostatic regulation in the skin and may improve our understanding of the pathobiology of tissue inflammatory diseases.
Original language | English (US) |
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Pages (from-to) | 4859-4864 |
Number of pages | 6 |
Journal | Journal of Immunology |
Volume | 196 |
Issue number | 12 |
DOIs | |
State | Published - Jun 15 2016 |
Externally published | Yes |
ASJC Scopus subject areas
- Immunology and Allergy
- Immunology